Pharmacodynamics : intracellular MIC ?

Expression of activity depends on who you are and where you are

phagolysosomes

macrolides

aminoglycosides

cytosol:

fluoroquinolones

ansamycins

ß-lactams

pH = 7

pH < 6

intracellular MIC >>> MIC in broth

intracellular MIC ~ MIC in broth

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