Pharmacokinetics : intracellular MIC ?

Accumulation may help to reach a cellular concentration > MIC

• ß-lactams ? 1 x

• aminoglycosides < 1 to 2 x

• ansamycins 2 - 3 x

• tetracyclines 2 - 4 x

• fluoroquinolones 10 - 20 x

• macrolides 4 to > 100 x

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