How to predict efficacy in the intracellular milieu ?

PHARMACOKINETIC PARAMETERS

PHARMACODYNAMIC PARAMETERS

1

2

3

4

Penetration and retention (efflux!)

Accumulation

Subcellular distribution

and relocalization

Metabolisation and inactivation

5

6

Expression of activity

Bacteria responsiveness

7

Cooperation with host defenses

D

D

D’

4

2

3

3

5

6

5

6

3

7

7

1

Tulkens, Scand J Infect Dis, 1991, 74:209-217

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