Conclusions from Renal Function Assessments
GFR decrease observed with naproxen (500 mg BID) in older subjects (65-85 yrs) but not celecoxib (200 mg or 400 mg BID)
Small, consistent transient reductions in fractional excretion of sodium on both celecoxib and naproxen
Small increase in peripheral oedema, 2.1% vs 1.1% placebo (same observed on NSAID)
No evidence of clinically relevant renally-mediated events
- No effect on incidence of hypertension
- No increased incidence of hypertension with ACE inhibitors, b-blockers, calcium antagonists, diuretics