Localization of COX-1 and COX-2 in the kidneys
+=COX-1 present
+=COX-2 present
Dog
Rat
Monkey
Man
Renal Vasculature
(Arteries, Arterioles, Veins)
+
+
+
+
+
+
+
Glomerulus
+
+
Macula Densa
+ (+++)
+ (+++)
(-)
Interstitium
+
+
+
+
+
Thick Ascending Loop
+ (+++)
+ (+++)
Collecting Ducts
+ + +
+ + +
+ +
+ +
Khan KN et al. Toxicol Pathol 1998;26(1):137-42.
(+++) = expression with volume depletion
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