Specificity of Celecoxib in vivo

J

J

J

J

J

J

0

20

40

60

80

100

120

0

0.1

1

10

100

500

Dose (mg/kg p.o.)

Gastric PG (COX-1)

J

Inflammatory PG (COX-2)

PG (% Control)

Smith CJ, PNAS, 1998, 95, 13313-18

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