Selectivity of COX Inhibitors in vivo

• Carrageenan air pouch

  • High levels of PG produced via COX-2
  • Provides a biochemical measure of COX-2 inhibition in vivo

• Gastric prostaglandin production

  • GI mucosa expresses COX-1 exclusively
  • Measure of the effect of COX inhibitors on steady state PG levels

Smith CJ et al, PNAS, 1998,95,13313-18

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