NSAID Ulcers and Ulcer Complications
Endoscopic ulcer point prevalence: 10-30%
Ulcer complications: 2-4% per year
Most (ᢈ%) hospitalizations for GI bleed occur without previous symptoms
Inhibition of prostaglandin synthesis is principal mechanism for GI damage
Use of antacids or H2 antagonists do not prevent NSAID induced gastric ulcers
Singh G et al. Am J Med 1998;105(1B):31S-8S.
Geis GS et al. J Rheumatol 1991;18:11-14.