NSAIDs toxicity

endoscopic

ulcers [3]

perforation or

haemorrhage [4]

Death [5]

1.7

0.2

GI intolerability*

GI Mucosal Damage / Complications

* Range 20-50% based on - withdrawals for GI symptoms1 - community surveys for GI symptoms2

1. Kiff et al, Eur J Rheumatol, 1994; 2. Hardo et al, BJCP, 1993; 3. Graham DY et al, Am J Gastroenterol 1988;

4. Silverstein et al, Ann Int Med, 1995; 5. Blower et al, Aliment Pharmacol, 1997