The AAP(3’)-IIIa interactions with aminoglycosides have been determined*
1. Comparison of a modeled aminoglycoside (thick ball and stick style) and the structure obtained from independent NMR studies (thin line style). The models were superimposed using a least-squares procedure. Root mean square deviations are 3.4 Å.
* Thompson et al., The COOH Terminus of Aminoglycoside Phosphotransferase (3')-IIIa Is Critical for Antibiotic Recognition and Resistance, J. Biol. Chem., 2000
Antimicrobial Research Centre, and Departments of Biochemistry and Chemistry, McMaster University,