Combining it all …(Peak and 24h-AUC / MIC) as predictors of efficacy of FQ ...

PK/PD Bkpts (mg/L)

Drug Dosage AUC/MIC peak / MIC NCCLS

(mg/24h) (24h) Bkpts*

norfloxacin 800 0.1 0.2 < 4

ciprofloxacin 500 0.1 0.2 < 1

ofloxacin 400 0.2-0.4 0.3 - 0.4 < 2

levofloxacin 500 0.4 0.4 - 0.5 < 2

gatifloxacin 400 0.3 0.4 < 2

moxifloxacin 400 0.4 0.4 < 2

* US prescrib. inf. (adult of 60 kg) of NOROXIN®, CIPRO®, FLOXIN®, LEVAQUIN®, TEQUIN® and AVELOX®