Peak concentrations as a tool to determine acceptable sensitivities to fluoroquinolones (p.o.)

Drug Dosage Cmax

(mg/24h) (mg/L)

norfloxacin 800 2.4 *

ciprofloxacin 500 2.4 *

ofloxacin 400 3-4.5 *, +

levofloxacin 500 5-6 *, +

gatifloxacin 400 4.2 *

moxifloxacin 400 4.5 *

* US prescrib. inf. (adult of 60 kg) of NOROXIN®, CIPRO®, FLOXIN®, TEQUIN®,

LEVAQUIN®, and AVELOX®

+ first dose to equilibrium

PK/PD Bkpt

[Cmax / 12] (mg/L)

0.2

0.2

0.3 - 0.4

0.4 - 0.5

0.4

0.4

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