Anticancer drugs transporters : discovery

• Decreased retention of actinomycin D as the basis for cross-resistance in anthracycline-resistant sublines of P388 leukemia. Inaba-M; Johnson-RK Cancer-Res. 1977 Dec; 37(12): 4629-34

• Active efflux of daunorubicin and adriamycin in sensitive and resistant sublines of P388 leukemia. Inaba-M; Kobayashi-H; Sakurai-Y; Johnson-RK, Cancer-Res. 1979 Jun; 39(6 Pt 1): 2200-3

There is an active outward transport mechanism for anthracyclines in P388 leukemia cells and an enhanced activity of this efflux process renders cells highly resistant to the cytostatic and cytotoxic effects of ADR and DAU.

Previous slide

Next slide

Back to first slide

View graphic version