PPT Slide

Relation between retention and binding?

(Van Bambeke et al, 1998)

macrolides : huge accumulation and retention?

Drug extracellular concentration (mg/l)

Drug cellular concentration (mg/l)

10

-2

10

-1

10

0

10

1

10

2

10

0

10

1

10

2

10

3

10

4

10

5

Increase

in phospholipid

cellular content

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