PPT Slide

Implications in clinical practice?

Long-term therapy with azithromycin: after 7 days of culture

Morphology:

Biochemistry:

0.03 to 0.1 mg/l

Cathepsin B activity if 1 mg/l

Phospholipid content if 5 mg/l

Cholesterol content if 10 mg/l

(Van Bambeke et al, 1998)

macrolides : huge accumulation and retention?

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