Pharmacokinetic/ Pharmacodynamics in Drug Development and Evaluation
The combination of in vitro modelling, proper design of animal
model experiments, and the willingness to obtain sparse
pharmacokinetic information on patients in clinical trials allows
an in depth understanding of which aspects of drug exposure
are most closely linked to therapeutic outcome as well
By providing such information to clinicians, drug therapy
can achieve the goal of maximal therapeutic effect while
engendering the lowest probability of encountering a drug
exposure-related adverse event.