Pharmacokinetic/ Pharmacodynamics in Drug Development and Evaluation

Some achievements:

• once-daily dosing of aminoglycosides brought to effective  registration or reregistration in several countries of Europe
  • amikacin, netilmicin (from bid to qd)
  • isepamicin (registered essentially for qd dosing) 

• AUIC / peak to MIC ratios taken in large consideration for the development and appraisal of new fluoroquinolones
  • trovafloxacin
  • moxifloxacin

• beta-lactam and glycopeptide continuous infusion brought to clinical trials

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