MECHANISM OF ACTION OF FLUOROQUINOLONE ANTIBIOTICS (5)

THE PHARMACOPHORE COMMON TO ALL FLUOROQUINOLONES

N

X

8

C

O

R

5

R

6

R

7

R

1

O

O-

BINDING TO DNA

AUTO-ASSEMBLING DOMAIN

(for stacking)

BINDING TO

THE ENZYME

BINDING TO

THE ENZYME

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