MECHANISM OF ACTION OF FLUOROQUINOLONE ANTIBIOTICS (4)

TERNARY COMPLEX DNA - ENZYME - FLUOROQUINOLONE

FLUOROQUINOLONES:

4 stacked molecules

DNA GYRASE

catalytic subunits

DNA GYRASE

ATP binding subunits

COVALENTLY CLOSED

CIRCULAR DNA

(Shen, in Quinolone Antimicrobial Agents, 1993)

Previous slide

Next slide

Back to first slide

View graphic version