10th French-Belgian ABC meeting
Brussels, Belgium, October 19-20, 2012
Venue: Université catholique de Louvain, Medical Health Sector,
Avenue Mounier 51, 1200 Bruxelles, Belgium - Auditoire central C
Program (PDF)
Abstracts
Participants
Pictures (Album)

Contacts: Françoise Van Bambeke (francoise.vanbambeke@uclouvain.be / +32-2-764.73.78)
               Attilio di Pietro (a.dipietro@ibcp.fr / +33-4-72.72.26.29)
FRIDAY OCTOBER 19, 2012
14:00 Introduction: Barry Holland (Université de Paris Sud, Paris, France) :
The "Franco-Belge" ABC series: simple but successful

Session 1 Role of ABC transporters in physiology
14:10 Keynote lecture: Piet Borst (The Netherlands Cancer Institute, The Netherlands)
Finding physiological functions of drug transporters using KO mice, LC.MS and transportomics

14:50

 Giovanna Chimini (Centre d'Immunologie de Marseille- Luminy INSERM-CNRS-Aix Marseille Université, France)
ABCs, membrane and lipids, the Franco-Belgian connection
15:15 Cedric Govaerts (Université libre de Bruxelles, Bruxelles, Belgium)
Towards of cure for Cystic Fibrosis : Restoring mutant CFTR Function with Nanobodies

15:40

Two short communications from junior scientists

Mélanie Albérich, Cécile Menez, Anne Lespine.
Chronic oral treatment with ivermectin increases expression of genes involved in drug disposition in mice
INRA - UMR 1331, Université de Toulouse, INP, TOXALIM, Toulouse, France

Laure-Alix Clerbaux, Isabelle Gérin, Guido T. Bommer.
microRNA33 targets the ABCA1 pump and regulates cholesterol metabolism
Laboratory for chelical physiology, de Duve Institute, Brussels, Belgium
Coffee break
young investigators' awards
Session 2: Role of ABC transporters in pathology
16:30 Keynote lecture: Patrick Aubourg (University Paris-Descartes, Paris, France)
Function of ABCD1 and therapeutic approaches in X-linked adrenoleukodystrophy
17:10 Attilio Di Pietro (BMSSI, UMR5086 CNRS-Université Lyon 1, France)
Modulation of cancer cell multidrug ABC transporters
17:35 Harry Cuppens (Katholieke Universiteit Leuven, Leuven, Belgium)
Treatments that correct the basic defect in cystic fibrosis come to age: no real need to know the detailed function of CFTR
18:00 Two short communications from junior scientists

Géraldine Dessilly1*, Laure Elens1*, Nadtha Panin1, Arnaud Capron2, Jean-Baptiste Demoulin3, Vincent Haufroid1, 2
ABCB1 1199G>A genetic polymorphism influences tacrolimus intracellular accumulation in HEK293 and K562 recombinant cell lines.
1Louvain centre for Toxicology and Applied pharmacology, Institut de recherche expérimentale et clinique,; 2Department of Clinical Chemistry, Cliniques Universitaires Saint-Luc, 3De Duve Institute Brussels, Université catholique de Louvain, Belgium.

C. Vituret 1,2, G. Gonzalez 1, A. Di Pietro 2, M. Chanson 3, P. Boulanger 1, & S.S. Hong 1
Transfer of the CFTR chloride channel by membrane-derived microparticles as a therapeutic approach for cystic fibrosis.
1 Université Lyon I & INRA UMR-754, Lyon 2 Unité BM2SI, Université Lyon 1- CNRS UMR 5086, IBCP, Lyon 3 Laboratory of Clinical Investigation III, Faculty of Medicine, University of Geneva, FMR, Geneva , Switzerland
GET TOGETHER PARTY around Belgian specialties
SATURDAY OCTOBER 20, 2012
Session 3: ABC transporters: structure and mechanisms
9:00 Keynote lecture: Hendrik van Veen (University of Cambridge, UK)
Molecular mechanisms of ABC transporters and beyond
9:40 Jean-Michel Jault (Institut de Biologie Structurale, Grenoble, France)
Updated mechanism of multidrug ABC transporters from Bacillus subtilis
10:05 Bjorn Vergauwen (Ghent University, Ghent, Belgium)
ABC solute binding proteins involved in bacterial glutathione transport
10:30

2 short communications from junior scientists

Alice Verchère, Isabelle Broutin & Martin Picard
Functional investigation of a multidrug transporter of Pseudomonas aeruginosa
Laboratoire de Cristallographie et RMN Biologiques (CNRS UMR8015), Faculté de Pharmacie, Université Paris Descartes, Paris, France.

Lauriane Dury, Attilio Di Pietro and Hélène Cortay
Influence of the basal cellular level of glutathione in triggering MRP1-cells death
IBCP, UMR 5086, BMSSI, 69007 Lyon, France.
Coffee break
Session 4: ABC transporters in non mammalian cells
11:10 Keynote lecture: André Goffeau (Université catholique de Louvain, Louvain-la-Neuve, Belgium)
The fungal pleiotropic drug resistance alias MDR family
11:50 Lutz Schmitt (Institute of Biochemistry, Heinrich Heine University Düsseldorf, Germany) :
The haemolysin system from E. coli - a paradigm for type I secretion systems ?
12:15 Marc Boutry (Université catholique de Louvain, Louvain-la-Neuve, Belgium)
Plant drug smugglers
12:40

2 short communications from junior scientists

M. Issouf , F. Guegnard, C. Koch, C. Sauvé, C. Neveu and D. Kerboeuf
Role of P-glycoproteins in the installation of parasite nematodes in the host.
INRA, UR1282 Infectiologie Animale et Santé Publique, Nouzilly, France

Manuela Désirée Bienert1, Stephanie Elise Gerlitz Siegmund2, Anna Drozak1, Tomasz Trombik1, Alain Bultreys3, Ian Thomas Baldwin2, and Marc Boutry1
A Pleiotropic Drug Resistance transporter in Nicotiana tabacum is involved in defense against the herbivore Manduca sexta
1Institut des Sciences de la Vie, Université catholique de Louvain,Louvain-la-Neuve, Belgium; 2Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Jena, Germany; 3Département Sciences du vivant, Centre Wallon de Recherches Agronomiques,Gembloux, Belgium.
13:00 Conclusion: Francoise Van Bambeke (Université catholique de Louvain, Brussels, Belgium)
ABC meeting perspective: From Paris to Bruxelles to Paris …
 
VISIT OF BRUSSELS in the afternoon (optional)
as you have never seen it …

Brussels, the Cradle of Art Nouveau ...