? How does AZ inhibit pinocytosis ?

Azithromycin, a macrolide antibiotic that impairs endocytic trafficking, directly interacts with biomembranes and perturbs their organization and fluidity

D. Tyteca, A. Schanck, Y. F. Dufrêne, M. Deleu, P.J. Courtoy, P.M. Tulkens &

M.-P. Mingeot-Leclercq

(to be submitted)

? Selection of experimental system

? liposomes

? Langmuir-Blodgett monolayers

? J774 mouse macrophages

? Experimental tests

? interaction with membranes

? membrane organization in domains

? insertion of membrane probes in the plasma membrane

? membrane fluidity

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