? Could AZ affect earlier steps of the endocytic apparatus ?
? Selection of experimental system
? avidly accumulate azithromycin
? develop lysosomal phospholipidosis
? extensively characterized system
Azithromycin, a lysosomotropic antibiotic, impairs fluid-phase endocytosis in cultured fibroblasts
D. Tyteca, P. Van Der Smissen, F. Van Bambeke, K. Leys, P.M. Tulkens, P.J. Courtoy & M.-P. Mingeot-Leclercq
Eur. J. Cell Biol. 80: 466-478 (2001)