AMINOGLYCOSIDES- LIPIDS INTERACTIONSInhibition of lysosomal phospholipase activity

0

100

200

300

400

Drug concentration (µM)

0

20

40

60

80

100

Release of

lysophosphatidylcholine

(% control)

Gentamicin

Isepamicin

IC50 =

220 µM

IC50 =

100 µM

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