AMINOGLYCOSIDE-LIPIDS INTERACTIONSCorrelation between the theoretical and experimental studies

Aminoglycoside

isepamicin

amikacin

kanamycin A

kanamycin B

Interaction

detected by

equilibrium dialysis

Kd (µM)

47

30

7

6

Interaction

detected by

15N NMR

weak

medium

medium

strong

Calculated

interaction

(KJ / mol)

- 23.4

- 35.7

- 46.8

- 48.5

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