Etudes animales: justification des doses utilisées
Drug Duration clinical Clinical daily drug
(mg/kg) (days) dosea exposureb
Gentamicin 10 4-10 ~2 ~0.5
Netilmicin 10 10 ~1.7 ~0.4
Amikacine 40 10 ~2.7 ~ 0.7
Isepamicin 40 10 ~ 2.7 ~ 0.7
a suggested maintenance doses for an adult patient with an estimated creatinine clearance of 90 ml/min (gentamicin, 5.1 mg/kg; netimmicin, 6 mg/kg; amikacin, 15 mg/kg) or on the registered dosage in Belgium and many other contries for isepamicin.
b based on estimated AUC ratio, using the dose ratio defined in b and assuming apparent half-lifes of ~ 30 min rats and ~ 120 min in humans, respectively (?-elimination phases).