in vitro models to reduce the working load for in vivo toxicological studies

DRUG DEVELOPMENT

From in vitro to in vivo :

• pharmacokinetic parameters predictive of toxicity

• definition of target (organ and cell levels)

• optimalization of the safety profile of the molecule

• development of screening tests

In vivo only :

• cause of side effect ?

• detection of side effect ?

• reduction of side effect ?

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