Toxicodynamic models for the discovery of cellular alterations induced by macrolides

Mathematical versus experimental models ?

Increase

in phospholipid

cellular content

Drug extracellular concentration (mg/l)

Drug cellular concentration (mg/l)

10

-2

10

-1

10

0

10

1

10

2

10

0

10

1

10

2

10

3

10

4

10

5

Cc / Ce ? 100

Cc / Ce ? 1000

(Van Bambeke et al, 1998)

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