From pharmacokinetics to toxicodynamics ...

A

B

S

O

R

P

T

I

O

N

D

I

S

T

R

I

B

U

T

I

O

N

E

L

I

M

I

N

A

T

I

O

N

• Vd ?

concentration

in target organs

• prot. binding

• t ½ ?

retention in

the organism

• route of elimination

Toxicity

Drug

interactions

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