Table of Contents
In vitro toxicodynamic models to accelerate drug selection
and safety assessment
In vivo pharmacokinetics/pharmacodynamics of anti-infectives
PPT Slide
Why may anti-infectives be toxic?
From pharmacokinetics to toxicodynamics ...
Which Pharmacokinetic/Pharmacotoxicologic parameters
to take in consideration ?
PPT Slide
How can models help?
1. Toxicodynamic models for:
Toxicodynamic models for the understanding of aminoglycoside
nephrotoxicity
Toxicodynamic models for the understanding of aminoglycoside
nephrotoxicity
Toxicodynamic models for the understanding of aminoglycoside
nephrotoxicity
Toxicodynamic models for the understanding of aminoglycoside
nephrotoxicity
2. Toxicodynamic models for:
Toxicodynamic models for the discovery of cellular
alterations induced by macrolides
Toxicodynamic models for the discovery of cellular
alterations induced by macrolides
Toxicodynamic models for the discovery of cellular
alterations induced by macrolides
Toxicodynamic models for the discovery of cellular
alterations induced by macrolides
Toxicodynamic models for the discovery of cellular
alterations induced by macrolides
Toxicodynamic models for the discovery of cellular
alterations induced by macrolides
Toxicodynamic models for the discovery of cellular
alterations induced by macrolides
Pharmacokinetic parameters revisited in the light
of toxicodynamics
Pharmacodynamic parameters revisited in the light
of pharmacokinetics
? in vitro models to reduce the working load of
in vivo toxicological studies ?
? in vitro models to reduce the working load for
in vivo toxicological studies ?
in vitro models to reduce the working load for
in vivo toxicological studies
PPT Slide
Publications in toxicology : hit-parade of the
models used
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