Cellular and Molecular Pharmacology (UCL, Brussels, Belgium)

Université Catholique de Louvain (UCL-Bruxelles)

Department of Pharmaceutical Sciences
Cellular and Molecular Pharmacology Unit (Dir. Prof. P.M. Tulkens)

Published abstracts, by reverse chronological order
(oral or poster presentations at scientific meetings)
Last update: 22/01/2001
See also the indexed search or go back to the previous page for a list of our Original Papers (full papers), Reviews, Chapter of Books, Proceedings, Books, PhD Theses, Master Degree Dissertations, or Educational papers.

Pharmacodynamics of two beta-lactams and two fluoroquinolones against extracellular and intracellular Listeria monocytogenes.
Carryn S, Ouadrhiri Y, Van Bambeke F, Mingeot-Leclercq MP, Tulkens PM
In: 15th Symposium of the Belgian Society for Infectiology and Clinical Microbiology, Brussels, Belgium, (2000)
Identification and characterization of ciprofloxacin efflux transporter in murine J774 macrophages.
Michot JM, Van Bambeke F, Mingeot-Leclercq MP, Tulkens PM
In: 40th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, Canada, 662 (2000)
Azithromycin, a lysosomotropic antibiotic, impairs endocytosis in cultured macrophages.
Tyteca D, Van Bambeke F, Tulkens PM, Mingeot-Leclercq MP
In: 41st International Conference on the Biochemistry of Lipids, Haale (Saale), Germany, T3/28 (2000)
Modulation of the cellular accumulation of ciprofloxacin and moxifloxacin in J774 macrophages.
Uwamahoro MJ, Carryn S, Michot JM, Mingeot-Leclercq MP, Tulkens PM, Van Bambeke F
In: 40th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, Canada, 2268 (2000)
Azithromycin increases the activity of cathepsin B, a lysosomal endopeptidase, by inhibiting its degradation in rat embryo fibroblasts.
Gerbaux-Morlighem C, Van Bambeke F, Tulkens PM
In: 39th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, Cal., 1757 (1999)
Study of glycopeptide-dependent Enterococcus faecium clinical isolates by sequencing of the ddl gene and computer-aided modeling of the mutated D-Ala:D-Ala ligase.
Gholizadeh Y, Van Bambeke F, Prévost M, Fraimow HS, Chachaty E, Dever LL, Tulkens PM, Courvalin P
In: 39th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, Cal, 1447 (1999)
Structure and function of Enterococcus faecalis D-Alanyl:D-Alanine ligase by comparative computer-aided conformational analysis.
Prévost M, Van Belle D, Tulkens PM, Courvalin P, Van Bambeke F
In: 39th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, Cal., 1139 (1999)
Macrolide antibiotics (azithromycin and erythromycylamine) perturb the early stages of endocytosis in phagocytic and non-phagocytic cells.
Tyteca D, Leys K, Van Bambeke F, Tulkens PM, Mingeot-Leclercq MP
In: 39th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, Cal., 1756 (1999)
Azithromycin, a lysosomotropic antibiotic, perturbs the early stages of endocytosis in phagocytic and non-phagocytic cells.
Tyteca D, Van Bambeke F, Tulkens PM, Mingeot-Leclercq MP
In: European Congress of Cell Biology, Bologna, Italy, D-147 (1999)
Comparative studies of aminoglycoside-induced apoptosis in rat kidneys: study with gentamicin, netilmicin, amikacin, and isepamicin.
El Mouedden M, Laurent G, Mingeot-Leclercq MP, Tulkens PM
In: 38th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA, A88 (1998)
Apoptose induite par la gentamicine, un antibiotique lysosomotrope, en relation avec la surcharge lysosomale.
El Mouedden M, Laurent G, Mingeot-Leclercq MP, Tulkens PM
In: 2eme Congrès Scientifique VML (Vaincre les Maladies Lysosomales), Dijon, France, (1998)
In search of efflux pumps to fluoroquinolones in macrophages.
Michot JM, Decottignies A, Tulkens PM, Van Bambeke F
In: 11th Scientific meeting of the Société belge d'Infectiologie et de Microbiologie Clinique/Belgische Vereniging voor Infectiologie en Klinische Microbiologie, Gent, Belgium, ----- (1998)
Lysosomal alterations induced in cultured cells models by long-term exposure to low, clinically meaningful concentrations of azithromycin.
Michot JM, Gerbaux C, Van Bambeke F, Bouvier d'Yvoire M, Tulkens PM
In: 38th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, Cal., I052 (1998)
Uptake of esters prodrugs of ampicillin (pivampicillin, phthalimidomethylampicillin, S-acetyl-2-thioethylampicillin) in macrophages and PMN with intracellular liberation of ampicillin.
Paternotte I, Burton S, Sonveaux E, Tulkens PM
In: 38th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, Cal., F7 (1998)
Perturbation of membrane traffic induced in cultured cells by azithromycin, a lysosomotropic antibiotic.
Tyteca D, Van Bambeke F, Tulkens PM, Mingeot-Leclercq MP
Arch Physiol Biochim (1998) 106:B28.
Perturbation of endocytosis induced by azithromycin in a model of cultured cells.
Tyteca D, Van Bambeke F, Tulkens PM, Mingeot-Leclercq MP
In: 7th Symposium on Pharmacodynamics of Antimicrobials, International Society of Antiinfective Pharmacology, San Diego, Cal., ------- (1998)
Study of vancomycin-dependent Enterococcus faecalis clinical isolates and of in vitro revertant mutants.
Van Bambeke F, Chauvel M, Reynolds PE, Fraimow HS, Courvalin P
In: 38th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, Cal., C086 (1998)
Understanding the mechanism of aminoglycoside-induced apoptosis and establishing its significance in relation with clinical toxicity of these drugs.
El Mouedden M, Laurent G, Mingeot-Leclercq MP, Tulkens PM
In: 9th Scientific meeting of the Société Belge d'Infectiologie et de Microbiologie Clinique/Belgische Vereniging voor Infectiologie en Klinische Microbiologie, Verviers, Belgium, 11 (1997)
Pénétration intracellulaire d'oligonucléotides et de peptides par encapsulation dans des liposomes.
Kerkhofs A, Mingeot-Leclercq MP, Sonveaux E
In: Semaine scientifique des sciences de la vie, Bruxelles, Belgium, (1997)
pH-sensitivity, leakage efficiency and endocytosis pathway of pH-sensitive liposomes DOPE/CHEMS AND DOPE/OA.
Kerkhofs A, Van Bambeke F, Sonveaux E, Tulkens PM, Mingeot-Leclercq MP
In: 7th Forum of pharmaceutical sciences, Blankenberg, Belgium, (1997)
Could pH-sensitive liposomes be used as drug delivery systems into cells.
Kerkhofs A, Van Bambeke F, Tulkens PM, Remacle C, Mingeot-Leclercq MP
Influence of low doses of azithromycin on lysosomal metabolism in cultured rat embyo fibroblats.
Michot JM, Van Bambeke F, Gerbaux C, Montenez JP, Tulkens PM
Arch Physiol Biochem (1997) 105:B11.
Comparative studies of lysosomal phospholipidosis induced by four macrolides.
Montenez JP, Van Bambeke F, Piret J, Brasseur R, Tulkens PM, Mingeot-Leclercq MP
In: 37th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, Canada, F266 (1997)
pH-sensitive liposomes: pH-sensitivity, leakage efficiency, endocytosis and natural targeting to the acidic compartment.

In: Liposome Advances. Progress in drug and vaccine delivery. Centre for Drug Delivery Research, London, (1996)
Computer-aided prediction of macrolide antibiotics concentrations in human circulating polymorphonuclear leucocytes.
Bouvier d'Yvoire M, Tulkens PM
Gentamicin causes lysosomal storage disorder (phospholipidosis) and apoptosis in cultured renal cells and rat fibroblasts.
El Mouedden M, Laurent G, Tulkens PM
In: 24th meeting of the Federation of the European Societies of Biochemistry, Barcelona, Spain, ----- (1996)
Correlation between lysosomal phospholipidosis and apoptosis induced by aminoglycosides: in vitro comparative study with gentamicin, netilmicin, and isepamicin.
El Mouedden M, Laurent G, Piret J, Mingeot-Leclercq MP, Tulkens PM
In: Programme and abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, La., A86 (1996)
Paradoxical increase of the activities of lysosomal enzymes in lysates of rat embryo fibroblasts incubated with azithromycin.
Gerbaux C, Van Bambeke F, Piret J, Morlighem G, Tulkens PM
In: 36th Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, La., A84 (1996)
pH-sensitive liposomes: pH-sensitivity, leakage efficiency, endocytosis, and natural targeting to the acidic compartments.
Kerkhofs A, Van Bambeke F, Sonveaux E, Tulkens PM, Mingeot-Leclercq MP
In: Liposome Advances (Progress in drug and vaccine delivery), London, England, A 42 (1996)
Interaction of cationic lysosomotropic antibiotics with negatively-charged membranes. II. Molecular characterization by biophysical and computer-aided conformational studies.
Mingeot-Leclercq MP, Montenez JP, Van Bambeke F, Schanck A, Brasseur R, Tulkens PM
In: 24th Meeting of the Federation of European Biochemical Societies, Barcelona, Spain, PS23-48 (1996)
Azithromycin causes an accumulation of lipids in lysosomes of cultured cells: Biochemical mechanism and potential relationship with its long-time retention in cells.
Montenez JP, Van Bambeke F, Mingeot-Leclercq MP, Piret J, Brasseur R, Tulkens PM
In: 36th Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, La., A85 (1996)
Intracellular activity of azithromycin in relation to its cellular disposition towards bacteria infecting distinct subcellular compartments.
Scorneaux B, Ouadrhiri Y, Anzalone G, Tulkens PM
In: 3d International Conference on the Macrolides, Azalides and streptogramins, Lisbon, Portugal, 4.17 p.42 (1996)
In vitro comparative studies of the interactions of gentamicin and azithromycin with membrane lipids: contribution to the understanding of the molecular mechanism by which they cause a lysosomal phospholipidosis in cultured cells.
Tyteca D, Belaabidia L, Montenez JP, Van Bambeke F, Mingeot-Leclercq MP, Piret J, Brasseur R, Tulkens PM
Arch Physiol Biochem (1996) 104:B22.
Perturbation of endosome-lysosome fusion induced in cultured cells by two lysosomotropic antibiotics (azithromycin, gentamicin) causing a lysosomal phospholipidosis.
Van Bambeke F, Montenez JP, Mingeot-Leclercq MP, Nachega J, Courtoy PJ, Tulkens PM
In: Page-Wood International Symposium on Membrane Traffic in Health and Disease, Cleveland, Ohio, 42 (1996)
Interaction of cationic lysosomotropic antibiotics with negatively-charged membranes. I. Binding, inhibition of lysosomal phospholipase A1 and influence on bilayer aggregation/fusion.
Van Bambeke F, Montenez JP, Mingeot-Leclerq MP, Belaabidia L, Tyteca D, Tulkens PM
In: 24th Meeting of the Federation of European Biochemical Societies, Barcelona, Spain, PS23-47 (1996)
Effect of human recombinant interferon-gamma on the intracellular activities of antibiotics against L. monocytogenes in a model of THP1 (human macropahges) cell line.
Anzalone G, Scorneaux B, Ouadrhiri Y, Tulkens PM
In: 19th Intern. Congress of Chemotherapy, Montreal, Quebec, Canada/Can. J. Infect. Dis. 6 suppl. C, 4170 (1995)
Prédiction des concentrations de macrolides dans les polymorphonucléaires humains circulants in vivo.
Bouvier d'Yvoire MJY, Tulkens PM
In: 15eme Réunion Interdisciplinaire de Chimiothérapie Anti-infectieuse/15th Interdisciplinary Meeting of Anti-infectious Chemotherapy, Paris, France, 372/P24 (1995)
Pharmacokinetics of aztreonam in infants after liver transplantation.
Bruno C, Ibrahim S, Clement de Clety S, Moulin D, Tulkens PM
In: Satellite Symposum on Pharmacodynamics of Antimicrobials, International Society of Antiinfective Pharamcology, Québec, Québec, Canda, 5 (1995)
Oxidant-scavenging activities of ceftazidime and other beta-lactams: evidence for a specific effect toward HCLO.
Carreer R, Sibille Y, Tulkens PM
In: 19th Intern. Congress of Chemotherapy, Montreal, Quebec, Canada/Can. J. Infect. Dis. 6 suppl. C, O670 (1995)
Gentamicin causes apoptosis in renal tubule epithelium of rats treated at low, clinically relevant doses.
El Mouedden M, Laurent G, Taper HS, Tulkens PM
In: 35th Interscience Conference on Antmicrobial Agents and Chemotherapy, San Francisco, Cal., 123 (1995)
Would lysosomal phospholipidosis cause cell death by apoptosis ?.
El Mouedden M, Laurent G, Taper HS, Piret J, Tulkens PM
In: 10th European Study Group on Lysosomal Diseases Workshop, Cambridge, U.K., (1995)
Phospholipiduria (PLU) for the early detection of aminoglycosides (AG)-induced renal alterations and toxicity: Overview of animal and clinical data.
Ibrahim S, Tulkens PM
Toxicol Lett (1995) 78 Supl.1:41. Journal impact factor: 1.242
Aztreonam pharmacokinetic parameters in pediatrics after liver transplant.
Ibrahim S, Bruno C, Clement de Clety S, Moulin D, Tulkens PM
In: 19th Intern. Congress of Chemotherapy, Montreal, Quebec, Canada/Can. J. Infect. Dis. 6 suppl. C, 4069 (1995)
Renal tolerance of liposomal amikacin in HIV+ patients: a pilot multiple parameters study.
Ibrahim S, Van Laethem Y, Hermans P, O'Doherty E, Eestermans GHE, Clumeck N, Tulkens PM
In: 35th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, Cal., A121 (1995)
Serum pharmacokinetic parameters and penetration of aztreonam in sputum of patients with cystic fibrosis.
Leto ML, Byl B, Bruno C, Ibrahim S, Baran D, Tulkens PM, Thys JP
In: 5ème réunion scientifique de la Société Belge d'Infectiologie et de Microbiologie Clinique, Leuven, belgium, --- (1995)
Macrolide antibiotics induce a cell overloading with cholesterol from exogenous origin: studies in clutured fibroblasts and comparison between azithromycin, dirithromycin, and erythromycin.
Montenez JP, Piret J, Tulkens PM
In: Eurotox 95 (Toxicology from cells to man), Prague, Czech Republic, (1995)
Differentiation of macrophages (THP-1 cell line) allows ceftazidime to exert a bactericidal action towards ingested S. aureus.
Ouadrhiri Y, Scorneaux B, Sibile Y, Tulkens PM
In: 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, Cal., 916 (1995)
Lysosomal changes induced by neomacrolides in cultured fibroblasts: comparative studies with azithromycin and dirithromycin.
Piret J, Gerbaux C, Montenez JP, Tulkens PM
In: 19th Intern. Congress of Chemotherapy, Montreal, Quebec, Canada/Can J. Infect. Dis. 6 suppl C, 3202 (1995)
31P NMR of negatively-charged liposomes interacting with aminoglycosides.
Schanck A, Van Bambeke F, Tulkens PM, Mingeot-Leclercq MP
In: Comptes-rendus du GERM XIV, Anglet-Biarritz, France, 60 (1995)
Intracellular bacteria drive cell-associated fluoroquinolones from the cytosol to the infected compartment: importance of the sensitivity of the bacteria to the drug.
Scorneaux B, Tulkens PM
In: 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, Cal., A68 (1995)
Activity of dirithromycine against intracellular pathogens with distinct localizations in a model of J774 macrophages: comparison with erythromycin, roxithromycin and azithromycin.
Scorneaux B, Tulkens PM
In: 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, Cal., (1995)
Uptake, effelux, and subcellular distribution of minocycline and doxycycline in J774 macrophages.
Scorneaux B, Tulkens PM
In: 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, Cal., (1995)
Activities of RP59500 (quinupristin/dalfopristin) and macrolides against Legionella pneumophila in a model of J774 macrophages in relation to their cellular accumulation.
Scorneaux B, Tulkens PM
In: 15eme Réunion Interdisciplinaire de Chimiothérapie Anti-infectieuse/15th Interdisciplinary Meeting of Anti-infectious Chemotherapy, Paris, France, 373/P24 (1995)
Effect of interferon-gamma on the intracellular activity of antibiotics against L. monocytogenes in a model of THP-1 (human macrophages) cell line.
Scorneaux B, Anzalone G, Ouadrhiri Y, Sibille Y, Tulkens PM
In: 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, Cal., 108 (1995)
Activity of dirithromycin against intracellular pathogens with distinct localization in a model of J774 macrophages: comparison with erythromycin, roxithromycin and azithromycin.
Scorneaux B, Orfila J, Tulkens PM
In: 15eme Réunion Interdisciplinaire de Chimiothérapie Anti-infectieuse/15th Interdisciplinary Meeting of Anti-infectious Chemotherapy, Paris, France, 3/C1 (1995)
Contrasting bioavailabilities and/or expression of activity of fluoroquinolones and beta-lactams in Listeria monocytogenes.
Scorneaux B, Ouadrhiri Y, Anzalone G, Tulkens PM
In: 19th Intern. Congress of Chemotherapy, Montreal, Quebec, Canada/Can. J. Infect. Dis. 6 suppl. C, P4170 (1995)
Uptake, subcellular distribution and efflux of erythromycylamine in J774 macrophages incubated with dirithromycin: comparison with other macrolides.
Scorneaux B, Piret J, Montenez JP, Tulkens PM
In: 15eme Réunion Interdisciplinaire de Chimiothérapie Anti-infectieuse/15th Interdisciplinary Meeting of Anti-infectious Chemotherapy, Paris, France, 43/C5 (1995)
Aminoglycosides aggregate membranes and prevent phospholipid reorganization: comparative studies with gentamicin, amikacin, and isepamicin and correlation with nephrotoxicity.
Van Bambeke F, Mingeot-Leclercq MP, Schanck A, Brasseur R, Tulkens PM
In: 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, Cal., 913 (1995)
Deciphering the toxicological parameters of aminoglycoside nephrotoxicity: a combined biophysical and biochemical study of gentamicin, amikacin and isepamicin in interaction with phosphatidylinositol-containing lipid vesicles.
Van Bambeke F, Tulkens PM, Schanck A, Mingeot-Leclercq MP
In: Satellite symposium on pharmacodynamics of antimicrobials, International Society of Antinfective Pharamcology, Québec, Québec, Canada, 27 (1995)
Aminoglycoside antibiotics cause aggregation of negatively-charged membranes but inhibit the lipid reorganization necessary for their fusion.
Van Bambeke F, Tulkens PM, Schanck A, Mingeot-Leclercq MP
In: 19th Intern. Congress of Chemotherapy, Montreal, Quebec, Canada/Can. J. Infect. Dis. 6 suppl. C., 3009 (1995)
Activities of glycopeptide antibiotics (vancomycin, teicoplanin) towards intracellular methicillin-resistant and methicillin-susceptible S. aureus in a model of J774 macrophages in comparison with ciprofloxacin and rifampicin.
Bily A, Scorneaux B, Tulkens PM
In: 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, Orlando, Fl., E37 (1994)
Azithromycin increases the activities of several lysosomal enzymes when measured in lysates of rat embryo fibroblasts incubated with this antibiotic.
Gerbaux C, Piret J, Montenez J-P, Tulkens PM
In: 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, Orlando, Fl., A108 (1994)
Etude d'une nouvelle thésaurismose lysosomiale acquise induite par l'azithromycine: III. Effet paradoxal sur l'activité de la phospholipase A1 et d'autres hydrolases lysosomiales de fibroblastes en culture.
Gerbaux C, Piret J, Montenez J-P, Tulkens PM
In: Congrès National sur les Maladies Lysosomales, Saumur, France, 20 (1994)
Effects of azithromycin on the activities of several enzymes in rat embryo fibroblasts.
Gerbaux C, Piret J, Montenez J-P, Carlier M-B, Courtoy PJ, Tulkens PM
Arch Int Physiol Biochim (1994) 100:B55.
Increase of phospholipiduria in neonates treated with amikacin.
Ibrahim S, Langhendries JP, Bernard A, Tulkens PM
In: Future Trends in Chemotherapy, Geneva, Switzerland., 90 (1994)
Safety of azitromycin and erythromycin in long-term treatments: analysis of phospholipiduria and phospholipidosis in white blood cells.
Lambricht P, Courtoy PJ, Maldague P, Ibrahim S, Tulkens PM, Daniel RR
In: Future Trends in Chemothery, Geneva, Switzerland., 91 (1994)
Interaction of aminoglycoside and macrolide antibiotics with membranes. Effect on Ca2+ permeability.
Mingeot-Leclercq MP, Depienne L, Van Bambeke F, Montenez JP, Tulkens PM
Cell Biol Int Rep (1994) :17/2.
Synthesis, microbiological and in vitro toxicological evaluation of amino acid and peptide derivatives in position 6 prime of kanamycin A and netilmicin.
Mingeot-Leclercq MP, Kotretsou S, Constantinou-Kokotou S, Georgiadis MP, Brasseur R, Tulkens PM
In: 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, Orlando, Fl., F140 (1994)
Effect of aminoglycoside and macrolide antibiotics on membrane permeability.
Mingeot-Leclercq MP, Van Bambeke F, Schanck A, Depienne L, Montenez JP, Tulkens PM
In: FEBS Special Meeting Biological Membranes, Helsinki, Finland, 248 (1994)
Etude d'une nouvelle thésaurismose lysosomiale acquise induite par l'azithromycine : I. Augmentation des taux cellulaires de phospholipides et de cholestérol estérifié dans des fibroblastes en culture.
Montenez J-P, Carlier M-B, Garcia-Luque I, Piret J, Tulkens PM
In: 1er Congrès National sur les Maladies lysosomales, Saumur, France., 68 (1994)
Azithromycin induces a lysosomal phospholipidosis in cultured rat embryo fibroblasts.
Montenez J-P, Carlier MB, Piret J, Garcia-Luque I, Courtoy PJ, Tulkens PM
Cell Biol Int (1994) 17:15.
Azithromycin decreases the buoyant density of lysosomes and increases the lipid phosphorus content of non-phagocytic cells in culture.
Montenez JP, Carlier MB, Garcia-Luque I, Tulkens PM
In: 2d International Conference on the Macrolides, Azalides and Streptogramins, Venice, Italy, 210 (1994)
In vitro models for the study of the regulation of the activity of lysosomal phospholipase A1 by membrane lipids.
Piret J, Kishore BK, Tulkens PM
Cell Biol Int (1994) 17(2):14.
In vitro models for the study of the regulation by membrane lipids of the mode of gentamicin-induced inhibition of lysosomal phospholipase A1.
Piret J, Kishore BK, Tulkens PM
Cell Biol Int (1994) 17(2):13.
Lysosomal alterations induced by azithromycin in cultured rat embryo fibroblasts.
Piret J, Montenez J-P, Tulkens PM
In: 4th European Congress of Cell Biology, Prague, Czech Republic., 108 (1994)
Azithromycin induces a lysosomal phospholipidosis in cultured rat embryo fibroblasts.
Piret J, Montenez J-P, Tulkens PM
In: 11th Future Trends in Chemotherapy (Interdisciplinary World Congress on Antimicrobial and Anticancer Drugs), Geneva, Switzerland., 189 (1994)
Etude d'une nouvelle thésaurismose lysosomiale acquise induite par l'azithromycine : II. Inhibition de l'activité de la phospholipase A1 dans un système a-cellulaire et comparaison de mécanisme avec la gentamicine.
Piret J, Montenez J-P, Tulkens PM
In: 1er Congrès National sur les Maladies Lysosomales, Saumur, France., 64 (1994)
Biochemical analysis and mechanism of the phospholipidosis induced by macrolide antibiotics in cultured rat embryo fibroblasts.
Piret J, Montenez J-P, Tulkens PM
In: 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, Orlando, Fl., A108b (1994)
Extracellular and intracellular activities of azithromycin, isepamicin and sparfloxacin alone and in association against Mycobacterium avium complex.
Scorneaux B, Tulkens PM
In: 2d International Conference on the Macrolides, Azalides and Streptogramins, Venice, Italy, 165 (1994)
Intracellular infection by L. pneumophila and S. aureus modulates the subcellular distribution of fluoroquinolones but not that of macrolides in a model of J774 macrophages.
Scorneaux B, Tulkens PM
In: 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, Orlando, Fl., E31 (1994)
Influence of intracelular infection on the release of macrolides and fluoroquinolones from J774 macrophages.
Scorneaux B, Tulkens PM
In: 2d International Conference on the Macrolides, Azalides and Streptogramins, Venice, Italy, 209 (1994)
Quantitative comparison of the activities of different pharmacological classes of antibiotics against extracellular and intracellular forms of susceptible bacteria.
Scorneaux B, Tulkens PM
In: 2d International Conference on the Macrolides, Azalides and Streptogramins, Venice, Italy, 158 (1994)
Comparative intracellular activities of gentamicin, ampicillin, macrolides and fluoroquinolones against virulent L. monocytogenes and S. flexneri and their non-virulent mutants in J774 macrophages.
Scorneaux B, Tulkens PM
In: 2d International Conference on the Macrolides, Azalides and Streptogramins, Venice, Italy, 164 (1994)
Comparative activities of tretacyclines (tetracycline, oxytetracycline, doxycycline, minocycline) against two types of intracellular pathogens (S. aureus methicillin-sensitive and resistant; Chlamydia spp.) in a model of J774 macrophages.
Scorneaux B, Orfila J, Tulkens PM
In: 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, Orlando, Fl., E35 (1994)
Evaluation of the capacity of aminoglycoside antibiotics to induce aggregation or fusion of liposomes, measured by the dequenching of the fluorescence of octadecylrhodamine B chloride (R18).
Van Bambeke F, Mingeot-Leclercq MP, Depienne L, Tulkens PM
Cell Biol Int Rep (1994) :17/2.
Evaluation of aminoglycoside antibiotics capacity to induce aggregation or fusion of liposomes, by using 3 complementary fluorescence techniques.
Van Bambeke F, Mingeot-Leclercq MP, Depienne L, Tulkens PM
In: FEBS Special Meeting Biological Membranes, Helsinki, Finland, 247 (1994)
Aminoglycosides induce aggregation but not fusion of liposomes, as evidenced by biophysical and morphological approaches.
Van Bambeke F, Mingeot-Leclercq MP, Depienne L, Tulkens PM
In: 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, Orlando, Fl., A108a (1994)
Aminoglycoside antibiotics induced alterations in membrane permeability of liposomes to increasing molecular weight markers.
Van Bambeke F, Mingeot-Leclercq MP, Schanck A, Brasseur R, Tulkens P
Cell Biol Int Rep (1994) :17/2.
Once-a-day and twice-a-day schedules of amikacin are equally tolerated in Intensive Care Unit patients: a double blind, randomized, prospective study.
Van Laethem Y, Ibrahim S, Dachy B, Dechamps P, Stevens E, Hermans P, Franchioly P, Clumeck N, Sommereijns B, Tulkens PM
In: 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, Orlando, Fl., M88 (1994)
Double-blind, randomized comparison of the renal safety of amikacin once-a-day vs twice-a-day in intensive care unit (ICU) patients.
Van Laethem Y, Ibrahim S, Dechamps P, Stevens E, Hermans P, Kaufman L, Derde MP, Clumeck N, Tulkens PM
In: Future Trends in Chemotherapay, Geneva, Switzerland., 92 (1994)
Quantitative comparison of the activities of antibiotics against extracellular and intracellular forms of susceptible bacteria.
Crasson D, Scorneaux B, Tulkens PM
In: 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, La, 767 (1993)
Effect of azithromycin on the buoyant density of lysosomes in cultured fibroblasts.
Garcia-Luque I, Carlier MB, Tulkens PM
In: 6th European Congress of Clinical Microbiology and Infectious Diseases, Seville, Spain, 307 (1993)
Once-a-day administration of amikacin in neonates: assessment of nephrotoxicity and ototoxicity.
Langhendries JP, Battisti O, Betrand JM, François A, Darimont J, Ibrahim S, Tulkens PM, Bernard A, Scalais E
In: 5th European Congress of Biopharmaceutics and Pharmacokinetics, Brussels, Belgium/Drug Metabolism and Pharmacokinetics., 169 (1993)
Abstract
Aminoglycoside-induced increase in membrane permeability. II. Studies with cultured cells.
Mingeot-Leclercq MP, Van Bambeke F, Brasseur R, Tulkens PM
In: 11th International Biophysics Congress, Budapest, Hungary, C5.32 (1993)
Azithromycin decreases the buoyant density of lysosomes and increases the lipid phosphorus content of non-phagocytic cells in culture.
Montenez JP, Carlier B, Garcia-Luque I, Tulkens PM
In: 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, La, 310 (1993)
Influence of the lipid composition of membranes on the mode of inhibition of lysosomal phospholipase A1 activity by gentamicin in vitro.
Piret J, Kishore BK, Tulkens PM
In: 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, La, 592 (1993)
Influence of intracellular infection on the release of macrolides and fluoroquinolones from J774 Macrophages.
Scorneaux B, Tulkens PM
In: 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, La, 768 (1993)
Extracellular (extra) and intracellular (intra) activities of azithromycin, isepamicin, and sparfloxacin alone and in association against Mycobacterium avium complex.
Scorneaux B, Tulkens PM
In: 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, La, 1351 (1993)
Intracellular activities of macrolides against Mycobacterium avium complex in a model of J774 macrophages.
Scorneaux B, Carlier MB, Garcia-Luque I, Tulkens PM
In: 6th European Congress of Clinical Microbiology and Infectious Diseases, Sevilla, Spain, 230 (1993)
Penetration, accumulation and intracellular distribution of antibiotics: clinical implications.
Tulkens PM
In: 21ème Journées annuelles de la Société belge de Pédiatrie/21ste Jaarvergadering van de belgische Vereniging voor Kindergeneeskunde, -- (1993)
Alterations in membrane permeability induced by aminoglycoside antibiotics. Studies on liposomes and cells.
Van Bambeke F, Mingeot-Leclercq MP, Tulkens PM
Arch Int Physiol Biochim Biophys (1993) 101:B21.
Aminoglycoside induced increase of membrane permeability in liposomes and cultured cells.
Van Bambeke F, Mingeot-Leclercq MP, Depienne L, Tulkens PM
In: 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, La, 218B (1993)
Aminoglycoside-induced increase in membrane permeability. I. Studies with large unilamellar vesicles.
Van Bambeke F, Mingeot-Leclercq MP, Depienne L, Schanck A, Tulkens PM
In: 11th International Biophysics Congress, Budapest, Hungary, C5.31 (1993)
Comparative intracellular activity of antibiotics against virulent L. monocytogenes, S. flexneri and their non virulent mutants in a model of J774 macrophages.
Willot I, Scorneaux B, Tulkens PM
In: 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, La, 769 (1993)
Aminoglycoside-induced renal alterations: correlation between renal phospholipidosis and phospholipiduria, and modulation by the coadministration of piperacillin.
Ibrahim S, Gerard F, Kishore BK, Lambricht P, Wagner R, Tulkens PM
Renal Failure (1992) 14:67.
Aminoglycosides (AGs)-induced renal alterations: correlation between renal phospholipidosis (RPL) and phospholipiduria (PLU) and modulation by the coadministration of piperacillin (PIP).
Ibrahim S, Gerard F, Kishore BK, Lambricht P, Wagner R, Tulkens PM
Renal Failure (1992) 14:116.
Influence of the coadministration of poly-L-aspartic acid on the gentamicin-induced tenal phospholipidosis, qualitative and quantitative lysosomal alterations and cell turn-over.
Kishore BK, Ibrahim S, Lambricht P, Laurent G, Maldague P, Tulkens PM
Renal Failure (1992) 14:75.
Cytochemical and physicochemical characterization of the acute thesaurismosis induced by poly-D-glutamic acid in rat kidney cortex.
Kishore BK, Maldague P, Havaux X, Ibrahim S, Tulkens PM, Courtoy P
In: 5th International Congress on Cell Biology, Madrid, Spain, P4.1.122 (1992)
Acute lysosomal thesaurismosis of proximal tubular cells and proliferation of peritubular cells induced by poly-D-glutamic acid in rat kidney cortex.
Kishore BK, Maldague P, Laurent G, Lambricht P, Ibrahim S, Tulkens PM
Renal Failure (1992) 14:74.
Quantitative analysis of the auditory tolerance of amikacin and isepamicin in 2 cohorts of patients using low and high frequency audiometry.
Lambricht P, Derde MP, Kaufman L, Donnez J, Vandercam B, Tulkens PM
In: 32d Interscience Conference on Antimicrobial Agents and Chemotherapy, Anaheim, Cal., 1592 (1992)
A stable model of anesthetised and infused rats for single dose pharmacokinetic studies.
Lu F, Kishore BK, Tulkens PM
In: 13th European Workshop on Drug Metabolism (Europ. Society of Biochemical Pharmacology), Bergamo, Italy, (1992)
Pharmacokinetics and renal uptake of poly-L-aspartic and poly-L-glutamic acids in rats.
Lu F, Kishore BK, Tulkens PM
In: 32d Interscience Conference on Antimicrobial Agents and Chemotherapy, Annaheim, Cal., 295 (1992)
Paradoxical effects of leupeptin on the activity of cathepsin B in vitro and in cultured fibroblasts.
Montenez JP, Kishore BK, Tulkens PM
In: 1st Intern. Union of Biochemistry and Molecular Biology Conference (Biochemistry of Disease), Nagoya, Japan, ------- (1992)
Increased activities of cathepsin B and other lysosomal hydrolases in fibroblasts and bone tissue cultured in the presence of leupeptin.
Montenez J-P, Delaisse J-M, Vaes G, Tulkens PM, Kishore BK
In: 5th International Congress on Cell Biology, Madrid, Spain, P-3.6 318 (1992)
Kinetic parameters of native and delipidated rat liver lysosomal phospholipase A1 towards phosphatidylcholine. II. Mathematical modeling and statistical analysis of experimental data.
Piret J, Dalcq-Aubert A, Kishore BK, Tulkens PM
Arch Int Physiol Biochim (1992) 100:B62.
Evaluation and validation of in vitro models of inhibition of phospholipid catabolism by aminoglycosides.
Piret J, Kishore BK, Tulkens PM
In: 32nd Interscience Conference on Antimicrobial Agents and Chemotherapy, Anaheim, Cal., 294 (1992)
In vitro modulating effect of membrane phospholipids on the activity of lysosomal phosplipase A1: possible relevance to turn-over of membrane phospholipids in vivo.
Piret J, Kishore BK, Tulkens PM
In: 5th International Congress on Cell Biology, Madrid, Spain, P-4.3 50 (1992)
Kinetic parameters of native and delipidated rat liver lysosomal phospholipase A1 towards phosphatidylcholine I. Experimental design.
Piret J, Kishore BK, Tulkens PM
Arch Int Physiol Biochim (1992) 100:B62.
Activities of azithromycin, spafloxacin, gentamicin and ampicillin against a series of facultative and obligatory intracellular parasites in a model of J774 macrophages.
Scorneaux B, Tulkens PM
In: 32d Interscience Conference on Antimicrobial Agents and Chemotherapy, Anaheim, Cal., 1706 (1992)
Comparison of the intracellular activities of erythromycin and azithromycin against Mycobacterium avium complex in a model of J774 macrophages.
Scorneaux B, Tulkens PM
In: 32d Interscience Conference on Antimicrobial Agents and Chemotherapy, Anaheim, Cal., 1333 (1992)
Activities of macrolides and fluoroquinolones against Legionella pneumophila in a model of J774 macrophages in relation to their cellular accumulation.
Scorneaux B, Tulkens PM
In: 32d Interscience Conference on Antimicrobial Agents and Chemotherapy, Anaheim, Calif., 1701 (1992)
Intracellular activity of new macrolides and azalides.
Tulkens PM, Scorneaux B
In: 1st International Conference on the Macrolides, Azalides and Streptogramins, Santa Fe, New Mexico, 5 (1992)
Analysis of key pharmacokinetic parameters (Vd, t1/2) of isepamicin, a new aminoglycoside, in 2 cohorts of infected patients.
Wallemacq P, Leal T, Vandercam B, Therasse P, Lambricht P, Tulkens PM
In: 32d Interscience Conference on Antimicrobial Agents and Chemotherapy, Anaheim, Cal., 210 (1992)
Subcellular localization of a phosphorothioate oligonucleotide in eukaryotic cells..
Carlier MB, Lobberding A, Tulkens PM
In: Proceedings of the 17th International Congress of Chemotherapy, Berlin, Germany, (1991)
Accumulation, subcellular distribution and activity of azithromycin compared to roxithromycin and ciprofloxacin in J774 macrophages.
Carlier MB, Scorneaux B, Tulkens PM
In: 31st Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, Ill., 510 (1991)
Aminoglycosides-induced renal alterations: Correlation between renal phospholipidosis and phospholipiduria, and the modulation by co-administration of piperacillin..
Ibrahim S, Gerard F, Kishore BK, Lambricht P, Wagner R, Tulkens PM
In: Symposium on Acute Renal Failure, Chapel Hill, N. Carolina, 110 (1991)
Protective effect of piperacillin on netilmicin-induced early renal alterations..
Ibrahim S, Gerard F, Lambricht P, Kishore BK, Tulkens PM
In: 31st Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, Ill., 331 (1991)
Cytochemical characterization of the acute thesaurismosis induced by poly-D-glutamic acid in rat kidney proximal tubular cells.
Kishore BK, Maldague P, Havaux X, Tulkens PM, Courtoy P
Eur Arch Biol (1991) 102:220.
Effect of co-oxydextran on the early renal alterations induced by gentamicin in rats.
Kishore BK, Van Schepdael A, Laurent G, Lambricht P, Piret J, Claes PJ, Tulkens PM
In: 7th International Symposium on Nephrology (Kidney, Proteins and Drugs), Montecatini Terme, Italy, 64 (1991)
Addition of leupeptin, an inhibitor of cysteine proteinases, to the culture medium causes an increase of the activities of cathepsin B and other lysosomal hydrolases in lysates of cultured fibroblasts.
Montenez JP, Kishore BK, Tulkens PM
Arch Int Physiol Biochim (1991) 100:B18.
Estimation of binding parameters of single and double Michaelis-Menten equations by nonlinear optimization method.
Piret J, Dalcq-Aubert A, Kaufman L, Tulkens PM
In: Symposium on Receptors Signal Transduction and Drug Design, Antwerpen, Belgium, (1991)
Effect of composition of lipid vesicles on the activity and on the gentamicin-induced inhibition of rat liver lysosomal phospholipase A1.
Piret J, Kishore BK, Tulkens PM
In: Eurotox Congress, Maastricht, The Netherlands, 156 (1991)
Effect of delipidation of rat liver lysosomal phospholipase A1 on its activity towards phosphatidylcholine included in liposomes and on its inhibition by gentamicin.
Piret J, Kishore BK, Tulkens PM
In: American Society of Biochemistry and Molecular Biology Symposium (Biological Significance of Lipid Modification of Proteins), Keystone, Colo., (1991)
In vitro evaluation of polyanionic dextran and sugar derivatives as protectants against gentamicin-induced lysosomal phospholipidosis.
Piret J, Kishore BK, Van Schepdael A, Claes PJ, Tulkens PM
In: 1991 Eurotox Congress, Maastricht, The Netherlands, 155 (1991)
Comparative activity of sparfloxacin and erythromycin in a model of J774 macrophages infected with Chlamydia pneumoniae.
Scorneaux B, Orfila J, Tulkens PM
In: 31st Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, Ill., 511 (1991)
Targeting and non-targeting of antiinfective drugs for chemotherapy of intracellular infection.
Tulkens PM
In: Synthetic polymers as drug carriers. Interactions with blood, A. Baszkin, P. Ferruti, M.A. Marchisio & M.C. Tanzi ed., Eurobiomat Coordination Secretariat, Rudolf-Virchov-Clinic, Berlin, Germany, 175 (1991)
Immunocytochemical localization of epidermal growth factor in rat renal tissue after treatment with amikacin.
Bodart C, Nonclercq D, Toubeau G, Lambricht P, Tulkens PM, Heuson-Stiennon JA, Laurent G
J Cell Biol (1990) 111:98a.
Chemical modification of kanamycin B in the 6"-position.
Busson R, Delcourt J, Claes P, Vanderhaeghe H, Tulkens PM, Mingeot-Leclercq PM
In: Intern. Symposium Carbohydrate Chemistry, Yokoama, Japan, D032 (1990)
Uptake and subcellular localization of sparfloxacin (AT4140; RP64206) in phagocytic cells.
Carlier MB, Faraji S, Tulkens PM
In: 30th Interscience Conference Antimicrobial Agents and Chemotherapy, Atlanta, Georgia, 1243 (1990)
Uptake and subcellular localization of a phosphorothioate oligonucleotide in eukaryotic cells.
Carlier MB, L~êobberding A, Tulkens PM
In: 30th Interscience Conference Antimicrobial Agents and Chemotherapy, Atlanta, Georgia, 623 (1990)
Synthesis of 6"-modified 1-C-CH2OH-kanamycin B analogues.
Claes P, Van Schepdael A, Busson R, Vanderhaeghe H, Tulkens PM, Mingeot-Leclercq PM
In: Intern. Sympium on Carbohydrate Chemistry, Yokoama, Japan, D031 (1990)
Comparative analysis of the renal phospholipidosis and phospholipiduria induced by netilmicin, amikacin and isepamicin in animals and humans.
Ibrahim S, Lambricht P, Laurent G, Tulkens PM
In: 30th Interscience Conference Antimicrobial Agents and Chemotherapy, Atlanta, Georgia., 633 (1990)
Fibroblast cultures for the study and screening of agents (polyanions and protease inhibitors) for modulating aminoglycoside-induced lysosomal phospholipidosis.
Kishore BK, Montenez JP, Tulkens PM
In: Ann. Meet. Belg. Branch Europ. Tissue Culture Soc. / Contact Group NFWO-FNRS In vitro Cultures, Brussels, Belgium, (1990)
Leupeptin, an inhibitor of cathepsin B, prevents gentamicin-induced lysosomal phospholipidosis (LPL) in cultured fibroblasts and aides poly-L-glutamic acid to become protectant against LPL.
Kishore BK, Piret J, Lambricht P, Tulkens PM
In: 30th Interscience Conference on antimicrobial Agents and Chemotherapy, Atlanta, Georgia, 752 (1990)
Morphological study of the nephrotoxicity of co-oxydextran administered alone or in combination with gentamicin to rats.
Kishore BK, Van Schepdael A, Lambricht P, Laurent G, Claes P, Tulkens PM, Maldague P
In: Annual meeting of the European Society of Toxicology (EUROTOX'90), Leipzig, Germany, 42 (1990)
Effect of co-oxydextran on gentamicin-induced lysosomal phospholipidosis and cellular proliferation in rat renal cortex.
Kishore BK, Van Schepdael A, Lambricht P, Laurent G, Claes P, Maldague P, Tulkens PM
In: Annual meeting of the European Society of Toxicology (EUROTOX'90), Leipzig, Germany, (1990)
Evaluation of the safety of isepamicin in animal models and in humans.
Lambricht P, Matsumoto K, Leal T, Wallemacq P, Donnez J, Tulkens PM
In: 9th International Symposium on Future Trends in Chemotherapy, Geneva, Switzerland, 132 (1990)
Clinical pharmacokinetics of isepamicin compared to amikacin: a preliminary study in young patients suffering from pelvic inflammatory disease.
Leal T, Lambricht P, Donnez J, Tulkens PM, Wallemacq P
Quimica Clinica (1990) 9:321.
Binding of gentamicin to poly-L-glutamic and poly-L-aspartic acids: influence on the protectant effect of these polymers against aminoglycoside-induced nephrotoxicity.
Piret J, Kishore KB, Tulkens PM
J Pharm Belg (1990) 45:82.
Relationship between binding of gentamicin to negatively-charged lipids and inhibition of lysosomal phospholipase A1 towards phosphatidylcholine.
Piret J, Mingeot-Leclercq MP, Delfosse S, Tulkens PM
J Pharm Belg (1990) 45:82.
Ciblage intracellulaire des antibiotiques.
Tulkens P
Path Biol (1990) 38:312.
Efficacy and safety of aminoglycosides once-a-day (qd): experimental and clinical data.
Tulkens PM
In: Pharmacodynamics of Antibiotics-Consequences for Dosing, Stockholm, Sweden, 28 (1990)
Le ciblage et le pilotage du médicament vers une structure cellulaire: applications aux médicaments antiinfectieux.
Tulkens PM
In: Résumé des Conférences de la Journée Médicale de Charleroi 1990, Société de Médecine de Charleroi, Charleroi, Belg. ed., 15-18 (1990)
Pharmacodynamics and pharmacokinetics of aminoglycosides and beta-lactam antibiotics in relation to prophylaxis.
Tulkens PM
In: 1st International Conference on the Prevention of Infection, Nice, France, 69 (1990)
Target drugs for the treatment of intracellular infections.
Tulkens PM
In: Intern. Conference Mastitis: Physiology or Pathology, Ghent, Belgium, (1990)
Lysosomal storage disorders and toxicity induced in kidney by aminoglycosides and polyanionic peptides.
Tulkens PM
In: 2d European Workshop on Endocytosis (NATO Advanced Research Seminars), Paris, France, (1990)
Intracellular pharmacokinetics and localization of antibiotics as predictors of their efficacy against intraphagocytic infections.
Tulkens PM
In: Pharmacodynamics of Antibiotics-Consequences for Dosing, Stockholm, Sweden, 26 (1990)
Macrophage and fibroblast cell cultures for the assessment of activity and modulation of toxicity of antimicrobials.
Tulkens PM, Kishore BK
In: 30th Interscience Conference on Antimicrobial Agents and Chemotherapy, Atlanta, Georgia, S-24 (1990)
Intracellular penetration and accumulation of antibiotics in relation to effectiveness.
Tulkens PM, Carlier MB, Scorneaux B, Zenebergh A
In: Hospital Infection towards the Year 2000 (2d Intern. Conf. Hospital Infection Society), London, U.K., (1990)
New insights into the biology of nephrotoxicity.
Tulkens PM, Kishore BK, Maldague P, Laurent G
In: 3d Annual International Consensus on Supportive Care in Oncology, Brussels, Belgium, S.C. Schimpff and J. Klastersky ed., 195 (1990)
Synthesis, microbiological and in vitro toxicological evaluation of kanamycin B analogues modified in 6" and in 6" and C1 positions.
Van Schepdael A, Vanderhaeghe HJ, Busson R, Claes P, Verbist L, Mingeot-Leclercq MP, Tulkens PM
In: 30th Interscience Conference Antimicrobial Agents and Chemotherapy, Atlanta, Georgia, 435 (1990)
Tolerance and efficacy of amikacin once-a-day vs twice-a-day: prospective, controlled study in 40 women suffering from pelvic inflammatory disease.
Brulein V, Jacqmin Ph, Ibrahim S, Donnez J, Delm{e M, Gersdorff M, Tulkens PM
In: 4th European Congress of Clinical Microbiology, Nice, France, 42 (1989)
Evaluation of the safety and efficacy of amikacin once-a-day (qd) in 20 patients suffering from pelvic inflammatory disease.
Brulein V, Jacqmin Ph, Ibrahim S, Kaufman L, Derde MP, Donnez J, Tulkens PM
Zeits Antimikrob Antineopl Chemoth (1989) suppl. 1:332.
Combined biochemical and morphometrical evaluation of aminoglycoside nephrotoxicity at low, therapeutic doses in the rat.
Carlier MB, Laurent G, Maldague P, Tulkens PM
In: 1st Conference of the European Society for Analytical Cellular Pathology, Schloss Elmau, West Germany, (1989)
Activity of 4 fluoroquinolones (pefloxacin, ciprofloxacin, BMY40062, and BMY40868) against intracellular S. aureus in J774 macrophages.
Carlier MB, Scorneaux B, Maquet M, Tulkens PM
In: 29th Interscience Conference Antimicrobial Agents and Chemotherapy, Houston, Tx., 159 (1989)
Activities of erythromycin and roxithromycin against Chlamydia trachomatis in a model of J774 macrophages in relation with their cellular accumulation.
Colson I, Orfilla J, Tulkens PM
In: 29th Interscience Conference Antimicrobial Agents and Chemotherapy, Houston, Tx., 158 (1989)
Influence of gangliosides on the activity of lysosomal phospholipases and their inhibition by aminoglycoside antibiotics.
Delfosse S, Mingeot-Leclercq MP, Piret J, Tulkens PM
Arch Int Physiol Biochim (1989) 97:B138.
Analysis of the pharmacokinetics, efficacy and safety of once-a-day administration (qd) of 2 aminoglycosides, netilmicin and amikacin, vs their conventional schedules in pelvic inflammatory disease.
Donnez J, Clerckx-Braun F, Jacqmin Ph, Brulein V, Tulkens PM
In: 1st World Congress for Infectious Diseases in Obstetrics and Gynaecology, Hawaii, 48/22 (1989)
Effect of schedule of aminoglycosides administration on urinary phospholipids excretion.
Ibrahim S, Clerckx-Braun F, Jacqmin Ph, Donnez J, Brulein V, Tulkens PM
In: 4th Intern. Nephrotoxicity Symposium, Guildford, U.K., 23 (1989)
Effect of schedule of aminoglycosides administration on urinary phospholipids excretion..
Ibrahim S, Clerckx-Braun F, Jacqmin P, Donnez J, Brulein V, Tulkens PM
Renal Failure (1989) 11:250.
Analysis of safety, pharmacokinetics and efficacy of once-a-day administration of netilmicin and amikacin versus their conventional schedules in pelvic inflammatory disease patients.
Ibrahim S, Derde MP, Kaufman L, Clerckx-Braun F, Jacmin Ph, Donnez J, Tulkens PM
In: 4th Intern. Nephrotoxicity Symposium, Guilford, U.K., 24 (1989)
Analysis of safety, pharmacokinetics and efficacy of once-a-day administration of netilmicin and amikacin versus their conventional schedules in pelvic inflammatory disease patients..
Ibrahim S, Derde MP, Kaufman L, Clerckx-Braun F, Jacqmin Ph, Donnez J, Tulkens PM
Renal Failure (1989) 11:251.
Analyse des paramètres d'efficacité, de toxicité et de pharmacocinétique de l'administration uniquotidienne (qd) de 2 aminoglycosides, la nétilmicine et l'amikacine comparée aux schémas conventionnels.
Ibrahim S, Donnez J, Clerckx-Braun F, Brulein V, Jacqmin Ph, Kaufman L, Tulkens PM
In: Réunion Interdisciplinaire de Chimiothérapie Antiinfectieuse, Paris, France, Société Française de Microbiologie/Société de Pathologie Infectieuse de Langue Française ed., 51 (15/C2) (1989)
Effect of aminoglycosides and of coadministration of poly-L-aspartic acid on urinary phospholipids excretion in rats: a comparative study.
Ibrahim S, Kishore BK, Lambricht P, Laurent G, Tulkens PM
In: 4th Intern. Nephrotoxicity Symposium, Guildford, U.K., 25 (1989)
Effect of aminoglycosides and of coadministration of poly-L-aspartic acid on urinary phospholipids excretion in rats: a comparative study.
Ibrahim S, Kishore BK, Laurent G, Tulkens PM
Renal Failure (1989) 11:251.
In vitro and in vivo evaluation of poly-L-aspartic and poly-L-glutamic acids as protectants against aminoglycoside-induced nephrotoxicity: further evidence for a lysosomal site of action.
Kishore BK, Ibrahim S, Lambricht P, Laurent G, Maldague P, Tulkens PM
In: 29th Interscience Conference Antimicrobial Agents and Chemotherapy, Houston, Tx., 296 (1989)
Inhibition of aminoglycoside-induced nephrotoxicity in rats by polyanionic peptides. I: in vitro and in vivo biochemical studies.
Kishore BK, Lambricht P, Ibrahim S, Laurent G, Tulkens PM
Renal Failure (1989) 11:170-171.
Inhibition of aminoglycoside-induced nephrotoxicity in rats by polyanionic peptides. I: in vitro and in vivo biochemical studies.
Kishore BK, Lambricht P, Ibrahim S, Laurent G, Tulkens PM
In: 6th Intern. Symposium of Nephrology (Kidney, Proteins and Drugs), Montecatini Terme, Italy, 58 (1989)
In vitro studies of anionic polypeptides as protectants against aminoglycoside-induced nephrotoxicity.
Kishore KB, Lambricht P, Laurent G, Tulkens PM
In: 5th Intern. Congress of Toxicology, Brighton, England, (1989)
Evaluation of micronomicin nephrotoxic potential in rats at low and high doses.
Lambricht P, Kishore BK, Ibrahim S, Wagner R, Maldague P, Laurent G, Tulkens PM
In: 29th Interscience Conference on Antimicrobial Agents and Chemotherapy, Houston, Tx., 299 (1989)
Morphological evidence of nephrotoxicity of poly-D-glutamic acid in rats.
Maldague P, Kishore BK, Lambricht P, Ibrahim S, Laurent G, Tulkens PM
Renal Failure (1989) 11:233-234.
Inhibition of aminoglycoside-induced nephrotoxicity in rats by polyanionic peptides. II: Morphological studies.
Maldague P, Kishore BK, Lambricht P, Laurent G, Tulkens PM
Renal Failure (1989) 11:171.
Morphological evidence of nephrotoxicity of poly-D-glutamic acid in rats.
Maldague P, Kishore KB, Lambricht P, Ibrahim S, Laurent G, Tulkens PM
In: 4th Intern. Nephrotoxicity Symposium, Guildford, U.K., 03 (1989)
Inhibition of aminoglycoside-induced nephrotoxicity in rats by polyanionic peptides. II. Morphological studies.
Maldague P, Kishore KB, Lambricht P, Laurent G, Tulkens PM
In: 6th Intern. Symposium of Nephrology "Kidney, Proteins and Drugs", Montecatini Terme, Italy, 59 (1989)
Influence of different negatively-charged phospholipids on the activity of lysosomal phospholipases towards phosphatidylcholine.
Mingeot-Leclercq MP, Tulkens PM
In: 19th Meeting of the Federation of the European Biochemical Societies, Rome, Italy, MO125 (1989)
Inhibition of phospholipase A1 activity towards phosphatidylcholine induced by gentamicin: effect of different negatively-charged phospholipids..
Mingeot-Leclercq MP, Brasseur R, Wagner R, Piret J, Tulkens PM
In: 19th Meeting of the Federation of European Biochemical Societies, Rome, Italy, FR167 (1989)
Redistribution of epidermal growth factor (EGF) immuno-reactivity in renal tissue after nephrotoxic injury.
Nonclercq D, Toubeau G, Laurent G, Lambricht P, Tulkens PM, Heuson-Stiennon JA
J Cell Biol (1989) 109:306a.
Comparative activity of erythromycin and 4 new macrolides (roxithromycin, dirithromycin, rokitamycin, midecamycin) against intracellular S. aureus in J774 macrophages.
Scorneaux B, Tulkens PM
In: 29th Interscience Conference on Antimicrobial Agents and Chemotherapy, Houston, Tx., 157 (1989)
pH exerts constrasting effects on cellular uptake and intracellular activity of a fluoroquinolone (pefloxacin) compared to a macrolide (roxithromycin) in a model of S. aureus-infected J774 macroph..
Scorneaux B, Pechère JC, Tulkens PM
In: 4th European Congress of Clinical Microbiology, Nice, France, 193 (1989)
Contrasting activities of ciprofloxacin, roxithromycin and clindamycin against intracellular S. aureus in J774 macrophages.
Scorneaux B, Zenebergh A, Tulkens PM
Zeits Antimikrob Antineopl Chemoth (1989) suppl. 1:144.
Activity of two macrolides (erythromycin, roxithromycin) that differ by their degree of cellular accumulation, against S. aureus phagocytozed by J774 macrophages.
Scorneaux B, Zenebergh A, Tulkens PM
In: 16th Intern. Congress of Chemotherapy, Jerusalem, Israel, (1989)
Intracellular penetration, localization and activity of antibiotics in macrophages.
Tulkens PM
Eur Resp Journ (1989) 2 (sppl.8):341.
Pharmacodynamics and pharmacokinetics of antibiotics: the case of beta-lactams and aminoglycosides.
Tulkens PM
In: Annual Meeting of the European Society for Surgery, Brussels, Belgium, (1989)
Modulating aminoglycoside nephrotoxicity.
Tulkens PM
In: 4th Intern. Nephrotoxicity Symposium, Guildford, U.K., 11 (1989)
Dosages d'antibiotiques intracellulaires.
Tulkens PM
In: A quoi sert le dosage du médicament anti-infectieux ? Applications en clinique, C. Carbon, J.J. Pocidalo et A. Crémieux ed., Arnette, s.a., Paris, 19-20 (1989)
Safety and efficacy of netilmicin once-a-day: preliminary results of a prospective randomized study in cancer patients with urinary tract infection.
Van der Auwera Ph, Aoun M, Bouguignon AM, Ibrahim S, Tulkens PM, Kaufman L, Derde MP
In: 16th Intern. Congress of Chemotherapy, Jerusalem, Israel, 195 (1989)
Tobramycin binding to renal brush border membrane is saturable at clinically-relevant concentrations.
Wagner R, Laurent G, Tulkens PM
In: 4th European Congress of Clinical Microbiology, Nice, France, 319 (1989)
Synthesis and study of 2-O-esters of the lincosaminide antibiotic pirlimycin and of a pirlimycin-mannosylated albumin conjugate targeted towards lysosomes of macrophages.
Böttcher P, Brison J, Moulliard C, Zenebergh A, Tulkens PM
In: 28th Interscience Conference Antimicrobial Agents and Chemotherapy, Los Angeles, Calif., 1013 (1988)
Uptake and subcellular localization of lomefloxacin (SC 47111) in phagocytic cells in comparison with pefloxacin and fleroxacin.
Carlier MB, Tulkens PM
In: 28th Interscience Conference Antimicrobial Agents and Chemotherapy, Los Angeles, CA, 52 (1988)
Effect of aminoglycosides on urinary excretion of phospholipids in humans treated with amikacin and netilmicin: a comparative study.
Ibrahim S, Clerckx-Braun F, Brulein V, Jacqmin Ph, Donnez J, Tulkens PM
In: 8th International Symposium on Future Trends in Chemotherapy, Pisa, Italy, 119 (1988)
Early detection of aminoglycoside-induced renal alterations in patients by measurement of urinary phospholipids excretion.
Ibrahim S, Van der Auwera Ph, Bernard A, Kaufman L, Derde MP, Meunier F, Tulkens PM
In: 28th Interscience Conference Antimicrobial Agents and Chemotherapy, Los Angeles, CA, 294 (1988)
Effect of netilmicin and amikacin on urinary phospholipids excretion in humans.
Ibrahim S, Van der Auwera Ph, Meunier F, Tulkens PM
In: EUROTOX'88, Muenchen, 1988, 124 (1988)
Comparative assessment of poly-L-aspartic and poly-L-glutamic acids as protectants against aminoglycoside-induced nephrotoxicity.
Kishore BK, Tulkens PM
In: EUROTOX'88, Munchen, September 4-7th, 1988, 40 (1988)
Abstract
Poly-L-aspartic acid, a protectant against aminoglycoside-induced nephrotoxicity, binds gentamicin in vitro : possible relevance to in vivo protective action.
Kishore BK, Kaêö,öllay Z, Tulkens PM
In: 8th International Symposium on Future Trends in Chemotherapy, Pisa, Italy, 121 (1988)
Mechanism of the protection afforded by poly-L-aspartic acid against gentamicin-induced nephrotoxicity: poly-L-aspartic acid binds gentamicin in lysosomes.
Kishore BK, Mingeot-Leclercq MP, Kaêö,öllay Z, Beauchamp D, Tulkens PM
In: 28th Interscience Conference Antimicrobial Agents and Chemotherapy, Los Angeles, CA, 293 (1988)
Increased levels of protein- and lipid-bound sialic acids in the renal cortex of rats injected with low doses of aminoglycoside antibiotics.
Kishore KB, Ibrahim S, Tulkens PM
In: 14th Congress of the International Union of Biochemistry, Prague, Czechoslovakia, TU:221 (1988)
Animal and in vitro studies of the early renal alterations induced by HAPA-gentamicin B (isepamicin) in comparison with amikacin and tobramycin.
Lambricht P, Matsumoto K, Kishore BK, Yernaux V, Rollmann B, Vanschepdaal A, Tulkens PM
In: 8th International Symposium on Future Trends in Chemotherapy, Pisa, Italy, 120 (1988)
Progrogues lysosomotropes de pénicillines.
Li K, Claessen M, Dumont P, Tulkens PM
In: 2me Journées Franco-Belges de Pharmacochimie (De la Conception à la Réalisation en Pharmacochimie), 43 (1988)
In vitro and in vivo evaluation of the early renal alterations induced by HAPA-gentamicin B (isepamicin).
Matsumoto K, Lambricht P, Kishore BK, Ibrahim S, Rollmann B, Laurent G, Tulkens PM
In: 28th Interscience Conference on Antimicrobial Agents and Chemotherapy, Los Angeles, Calif., 1503 (1988)
Uptake of fluoroquinolones in metabolically-inhibited phagocytes and in erythrocytes.
Scorneaux B, Carlier MB, Zenebergh A, Tulkens PM
In: 8th International Symposium on Future Trends in Chemotherapy, Pisa, Italy, 122 (1988)
Capture, distribution et activité intracellulaire de la roxithromycine dans les cellules phagocytaires en culture.
Tulkens PM, Carlier MB, Scorneaux B, Zenebergh A
In: Symposium sur les Nouveaux Concepts dans l'Antibiothérapie Ambulatoire, Berne, Suisse, 4 (1988)
Mechanism of the intracellular transport of diphtheria toxin. Fragment B-mediated endocytosis of large unilamellar vesicles containing encapsulated fragment A.
Wattiez R, Blondiau F, Falmagne P, Tulkens PM, Cabiaux V, Ruysschaert JM
Arch Int Physiol Biochim (1988) 96:B53.
Liposome-mediated intracytosolic delivery of bioactive molecules: transfer of encapsulated fragment A of diphtheria toxin to cytosol by means of fragment B-associated large unilamellar liposomes.
Wattiez R, Falmagne P, Cabiaux V, Defrise-Quertain F, Ruysschaert JM, Tulkens PM
In: 28th Interscience Conference Antimicrobial Agents and Chemotherapy, Los Angeles, CA, 322 (1988)
Binding and subcellular localization of rat monoclonal antibodies raised against bovine polymorphonuclear neutrophils.
Zenebergh A, Lebaupin C, Tulkens PM
Arch Int Physiol Biochim (1988) 96:B127.
Comparative regenerative response of rat kidney cortex after treatment with therapeutic doses of aminoglycosides.
Abid S, Carlier MB, Laurent G, Tulkens P, Maldague P
Chemioterapia (1987) 6(Suppl.2):329.
Evidence for receptor-mediated endocytosis of glycoconjugates by bovine mammary gland macrophages.
Böttcher P, Zenebergh A, Kaekenbeek P, Tulkens PM
Arch Int Physiol Biochim (1987) 95:B54.
In vitro study and conformational analysis of 1N-aminobutyryl derivatives of aminoglycosides in correlation with their nephrotoxic potential.
Carlier MB, Brasseur R, Ruysschaert JM, Tulkens PM
In: 28th Congress of the European Society of Toxicology, Strasbourg, France, P8 (1987)
Rat renal phospholipidosis in gentamicin and pefloxacin coadministration at low doses.
Carlier MB, Kaêö,öllay Z, Tulkens PM
In: 3d Intern. Symposium on Nephrotoxicity, Guildford, U.K., 11 (1987)
Reduction of aminoglycoside-induced renal alterations in rats by co-administration of piperacillin at clinically relevant doses.
Carlier MB, Laurent G, Tulkens PM
In: 15th Intern. Congress of Chemotherapy, Istanbul, Turkey, 883 (1987)
Uptake and subcellular distribution of 4 quinolones (pefloxacin, ciprofloxacin, ofloxacin, RO-23-6240) in phagocytes.
Carlier MB, Scorneaux B, Zenebergh A, Tulkens PM
In: 27th Interscience Conference Antimicrobial Agents and Chemotherapy, New York, N.Y., 622 (1987)
Handling of two macrolides, erythromicin and roxithromycin (RU 28965) by cultured macrophages.
Carlier MB, Zenebergh A, Tulkens PM
In: 15th Intern. Congress of Chemotherapy, Istambul, Turkey, 954 (1987)
Study of the tolerance of netilmicin once a day vs thrice a day (TID) in 28 cases of pelvic inflammatory disease.
Clerckx-Braun F, Donnez J, Ibrahim S, Kaêö,öllay Z, Delmee M, Gersdorff M, Tulkens PM
In: 27th Interscience Conference Antimicrobial Agents and Chemotherapy, New York, N.Y., 25 (1987)
Mécanisme du transport membranaire du fragment B de la toxine diphtérique. Interactions avec modèles de membrane et membranes naturelles.
Falmagne P, Wattiez R, Tulkens PM, Cabiaux V, Phalipon A, Kaczorek M, Ruysschaert JM
In: Colloque du Centenaire (Société Chimique de Belgique), Société Royale de Chimie, Bruxelles, 1.12 (1987)
Animal evaluation of the nephrotoxic potential associated with aminoglycoside x vancomycin combinations at low doses.
Francq-Dufief MP, Laurent G, Toubeau G, Heuson-Stiennon JA, Tulkens PM
In: 27th Interscience Conference Antimicrobial Agents and Chemotherapy, New York, N.Y., 23 (1987)
Patterns of phospholipids in renal cortex and urine of gentamicin-treated rats.
Ibrahim S, Tulkens P
Chemioterapia (1987) 6(Suppl.2):330-331.
Urinary phospholipids pattern in humans and animals after treatment with aminoglycoside antibiotics.
Ibrahim S, Kaêö,öllay Z, Clerckx-Braun F, Donnez J, Tulkens PM
In: 3d Intern. Symposium on Nephrotoxicity, Guildford, U.K., 12 (1987)
Urinary excretion of phospholipids during aminoglycoside therapy in humans.
Ibrahim S, Kaêö,öllay Z, Clerckx-Braun F, Donnez J, Tulkens PM
In: 28th Congress of the European Society of Toxicology, Strasbourg, France, P9 (1987)
Uptake and subcellular distribution of polyaspartic acid (a protectant against aminoglycoside-induced nephrotoxicity) in rat kidney cortex.
Kallay Z, Tulkens PM
In: 3d Intern. Symposium on Nephrotoxicity, Guildford, U.K., 14 (1987)
Renal accumulation and nephrotoxicity of gentamicin subcomponents C1, C1a and C2 after treatment at low doses in rats.
Kallay Z, Carlier MB, Rollmann B, Beauchamp D, Tulkens PM
In: 3d Intern. Symposium on Nephrotoxicity, Guildford, U.K., 13 (1987)
Synthèse peptidique en phase solide: un outil pour l'étude des relations structure-activité des protéines.
Michel A, Muyshont D, Tulkens PM
In: Colloque du Centenaire (Société Chimique de Belgique), Société Royale de Chimie, Bruxelles, (1987)
Conformational and biophysical analysis of the interactions between gentamicin or bis(betadiethylaminoethylether)hexestrol and negatively-charged phospholipid layers.
Mingeot-Leclercq MP, Brasseur R, Ruysschaert JM, Schanck A, Deleers M, Tulkens PM
In: Structure and Function of Molecules Affecting the Properties of Cellular Membranes, Paris, France, P.19 (1987)
Mechanism of inhibition of lysosomal phospholipases by gentamicin, an aminoglycoside antibiotic.
Mingeot-Leclercq MP, Laurent G, Tulkens PM
Arch Int Physiol Biochim (1987) 95:B85.
Changes in the morphology of negatively-charged liposomes induced by gentamicin and bis(beta-diethylaminoethylether)hexestrol.
Mingeot-Leclercq MP, Ronvaux-Dupal MF, Deleers M, Schanck A, Tulkens PM
In: Structure and function of Molecules Affecting the Properties of Cellular Membranes, Paris, France, P.18 (1987)
Structure-activity relationships studies of diphtheria toxin using synthetic peptides covering region 256-282 of fragment B.
Muyshont D, Michel A, Tulkens PM
Arch Int Physiol Biochim (1987) 95:B223.
Etude morphologique des cellules en prolifération dans le cortex rénal de rat traité à la tobramycine.
Nonclercq D, Toubeau G, Laurent G, Maldague P, Tulkens PM, Heuson-Stiennon JA
Micron Microscop Acta (1987) 18:203-204.
Ultrastructural characterization of tubular cells involved in repair of kidney cortex tissue after drug-induced tubular necrosis.
Nonclercq D, Yernaux V, Toubeau G, Laurent G, Heuson-Stiennon JA
Biol Cell (1987) 60:14a.
31P NMR and fluorescence depolarization study of model membranes in the presence of drugs inducing phospholipidosis.
Schanck A, Mingeot-Leclercq MP, Tulkens PM
In: 9th International Biophysics Congress, Jerusalem, Israel, 175 (1987)
Uptake and subcellular localization of fluoroquinolones in macrophages.
Scorneaux B, Carlier MB, Zenebergh A, Tulkens PM
Arch Int Physiol Biochim (1987) 95:B237.
Early alterations induced in rat kidney cortex by aminoglycosides: mechanisms and significance.
Tulkens PM
In: 70ème Congrès de Chimie du Canada/70th Canadian Chemical Conference, Québec, Qué., MEB-1-C (1987)
Mode of nephrotoxicity of aminoglycosides, and animal and human experience of the once-a-day regimen.
Tulkens PM
In: International Symposium on Netilmicin, Tokyo, Japan, Professional Postagraduate Services K.K., Tokyo, Japan, 10-11 (1987)
Drug-induced lysosomal phospholipidosis: biophysical and biochemical studies with aminoglycoside antibiotics and cationic amphiphiles.
Tulkens PM, Mingeot-Leclercq MP
In: Lipid Storage disorders: biological and medical aspects (NATO Avanced Research Workshop) Toulouse, 50 (1987)
Efficacy and safety of aminoglycosides once-a-day: animal data and randomized, controlled evaluation in patients suffering from pelvic inflammatory disease.
Tulkens PM, Clerckx-Braun F, Donnez J, Ibrahim S, Kaêö,öllay Z, Delm{e M, Giurgea-Marion L
In: The impact of novel dosing regimens on the safety and efficacy of aminoglycosides, Sorrento, Italy, 14-15 (1987)
Mechanism of the intracellular transport of bacterial toxins. Preparation and properties of an heteroconjugate between fragment B of diphtheria and fragment A of ricin toxins.
Wattiez R, Falmagne P, Tulkens PM
Arch Int Physiol Biochim (1987) 95:B161.
Comparative uptake and subcellular distribution of 4 closely-related lincosaminides, clindamycin, lincomycin, pirlimycin and glycyl-pirlimycin in phagocytes.
Zenebergh A, Boê~ttcher P, Brison J, Tulkens PM
In: 27th Interscience Conference Antimicrobial Agents and Chemotherapy, New York, N.Y., 1080 (1987)
Uptake and intracellular distribution of 2 fluoroquinolones, pefloxacin and ciprofloxacin, in phagocytes.
Zenebergh A, Carlier MB, Scorneaux B, Tulkens PM
In: 15th Intern. Congress of Chemotherapy, Istanbul, Turkey, 184 (1987)
Comparative regenerative response of rat kidney cortex after treatement with therapeutic doses of aminoglycosides.
Abid S, Carlier MB, Laurent G, Tulkens PM, Maldague P
In: 5th Mediterranean Congress of Chemotherapy, Cairo, Egypt, P346 (1986)
Accumulation and subcellular localization of two macrolides, erythromycin and roxithromycin (RU28965) in phagocytes.
Carlier MB, Zenebergh A, Tulkens PM
In: 26th Interscience Conference Antimicrobial Agents and Chemotherapy, New Orleans, La, 929 (1986)
Patterns of phospholipids in renal cortex and urine of gentamicin-treated rats.
Ibrahim S, Tulkens PM
In: 5th Mediterranean Congress of Chemotherapy, Cairo, Egypt, P-342 (1986)
Increased urinary excretion and change of patterns of phospholipids in gentamicin-treated rats.
Ibrahim S, Tulkens PM
In: 26th Interscience Conference Antimicrobial Agents and Chemotherapy, New Orleans, La, 27 (1986)
Characterization of phosphatidylinositol phospholipase C activity in rat liver lysosomes and of its inhibition by aminoglycoside antibiotics.
Lambricht P, Laurent G, Tulkens PM
Arch Int Physiol Biochim (1986) 94:B19.
Dose-response relationship of the cell proliferation induced in rat kidney cortex by tobramycin and netilmicin.
Laurent G, Beauchamp D, Rollmann B, Abid S, Maldague P, Tulkens PM
In: 26th Interscience Conference Antimicrobial Agents and Chemotherapy, New Orleans, La., 24 (1986)
Morphometry of the lesions induced by aminoglycosides in rat renal cortex and quantitative analysis of their repair by measure of 3H thymidine incorporation into DNA and labelling index.
Maldague P, Abid S, Carlier MB, Laurent G, Tulkens PM
In: VII Symposium International des Sciences Morphologiques, Louvain-en-Woluwe, Belgique, Archives of Biology, 69 (1986)
Early detection and morphometry of the lysosomal phospholipidosis induced by low, therapeutic doses of aminoglycosides.
Maldague P, Carlier MB, Abid S, Tulkens PM
In: IXth International Symposium on Drugs Affecting Lipid Metabolism, Florence, Italy, 196 (1986)
Molecular mechanisms of aminoglycoside-induced lysosomal phospholipidosis.
Mingeot-Leclercq MP, Laurent G, Schanck A, Ronveaux-Dupal MF, Deleers M, Tulkens PM
In: IXth International Symposium on Drugs Affecting Lipid Metabolism, Florence, Italy, 195 (1986)
Repair of kidney cortex after tobramycin-induced tubular necrosis : biochemical and ultrastructural characterization of the proliferative response.
Nonclercq D, Toubeau G, Laurent G, Maldague P, Tulkens PM, Heuson-Stiennon JA
Biol Cell (1986) 57:9a.
Renal phospholipidosis and cellular response of diabetic and control rats to low, non-toxic doses of gentamicin.
Vaamonde CA, Laurent G, Beauchamp D, Carlier MB, Ibrahim S, Maldague P, Tulkens PM
Kidney Int (1986) 29:311.
Morphological characterization of the regenerative response in rat kidney cortex during short treatments with aminoglycosides.
Abid S, Maldague P, Laurent G, Carlier MB, Beauchamp D, Tulkens PM
In: 25th Interscience Conference Antimicrobial Agents and Chemotherapy, Minneapolis, Minn, 709 (1985)
Reduction of gentamicin nephrotoxicity by concomitant administration of poly-L-aspartic acid and poly-L-asparagine in rats.
Beauchamp D, Laurent G, Maldague P, Tulkens PM
In: 26th Congress of the European Society of Toxicology, Kuopio, Finland, P23 (1985)
Use of an in vitro model to assess the aminoglycoside-phospholipid interactions, in relation to their nephrotoxicity.
Carlier MB, Brasseur R, Laurent G, Mingeot-Leclercq MP, Ruysschaert JM, Tulkens PM
In: Intern. Conference on Practical in vitro Toxicology, Reading, Berks., U.K., 6.21 (1985)
Animal study on the nephrotoxic potential of gentamicin-ceftazidime combination treatment at low doses.
Carlier MB, Laurent G, Beauchamp D, Maldague P, Rollmann B, Tulkens PM
In: 14th Intern. Congress of Chemotherapy, Kyoto, S24-9 (1985)
Effect of hydroxylation of the 2',6'diaminohexose moiety on the intrarenal accumulation of aminoglycoside antibiotics : comparison between kanamycin B, tobramycin, dibekacin and gentamicin.
Giurgea-Marion L, Tulkens PM
In: 14th Intern. Congress of Chemotherapy, Kyoto, P56-107 (1985)
Quantitative analysis of the phospholipid composition of rat kidney cortex after treatment with gentamicin, dibekacin, netilmicin and tobramycin at low doses (10 mg/kg).
Ibrahim S, Carlier MB, Laurent G, Tulkens PM
In: 25th Interscience Conference Antimicrobial Agents and Chemotherapy, Minneapolis, Minn, 708 (1985)
Use of fosfomycin salt of an aminoglycoside (S87351) to decrease its toxicity towards rat kidney cortex.
Laurent G, Beauchamp D, Carlier MB, Tulkens PM, Loibner H, Stütz P
In: 26th Congress of the European Society of Toxicology, Kuopio, Finland, P22 (1985)
The mechanism of gentamicin-induced inhibition of phosphatidylcholine hydrolysis.
Mingeot-Leclercq MP, Laurent G, Tulkens PM
In: 13th Congress of the International Union of Biochemistry, Amsterdam,The Nederlands, TH/443 (1985)
Accumulation and subcellular localization of a basic derivative of Penicillin G in J774 macrophages.
Renard C, Zenebergh A, Vanderhaeghe HJ, Claes PJ, Tulkens PM
In: 14th Intern. Congress of Chemotherapy, Kyoto, Japan, P1-5 (1985)
New systems for intracellular delivery of anti-infectious drugs.
Tulkens PM
In: 4th European Congress of Clinical Microbiology, Nice, France, 351 (1985)
In vitro model and semi-empirical conformational analysis to study and to compare the intrinsic nephrotoxicity of aminoglycoside antibiotics.
Tulkens PM, Laurent G, Carlier MB, Mingeot-Leclercq MP, Ruysschaert JM
In: 14th Intern. Congress of Chemotherapy, Kyoto, S24-4 (1985)
Renal cortical phospholipidosis in diabetic and control rats evaluated at similar cortical gentamicin accumulation.
Vaamonde C, Laurent G, Beauchamp D, Carlier MB, Ibrahim S, Maldague P, Tulkens PM
Clin Res (1985) 33:500A.
Uptake and release of clindamycin, lincomycin and pirlimycin by macrophages.
Zenebergh A, Renard C, Tulkens PM
In: 25th Interscience Conference on Antimicrobial Agents and Chemotherapy, Minneapolis, Minn, 555 (1985)
Subcellular localization of clindamycin in macrophages, PMN and fibroblasts : failure to demonstrate an intralysosomal sequestration.
Zenebergh A, Renard C, Tulkens PM
In: 14th Intern. Congress of Chemotherapy, Kyoto, Japan, P11-31 (1985)
S 87351 potential nephrotoxicity: in vitro study and in vivo evaluation at low doses.
Beauchamp D, Laurent G, Ruysschaert JM, Maldague P, Carlier MB, Tulkens PM
In: 24th Intersc. Conf. Antimicrob. Agents Chemother., Washington DC, 312 (1984)
Morphological and functional alteratons of lysosomes of kidney tubular cells during treatment with gentamicin.
Carlier MB, Giurgea-Marion L, Laurent G, Maldague P, Toubeau G, Heuson-Stiennon J, Tulkens PM
Biol Cell (1984) 52:109A.
Kidney alterations and recovery after acute loading with gentamicin at low and high doses using a perfused rat model.
Giuliano G, Paulus G, Verpooten G, Pattijn V, Pollet D, Laurent G, Tulkens P
In: 84th Annual Meeting, American Society for Microbiology, St-Louis, Mo., 55 (1984)
The gentamicin-induced alterations in rat kidney cortex are reversible up to threshold in cortical drug level.
Giuliano RA, Pattijn V, Pollet DE, Paulus G, Verpooten GA, De Broe ME, Tulkens P
In: IXth Intern. Congress of Nephrology, Los Angeles, Ca, (1984)
Kidney phospholipidosis and recovery after acute exposure to gentamicin with low and high doses in an infused rat model.
Giuliano RA, Paulus GJ, Verpooten GA, Pattijn V, Polled DE, Nouwen EJ, De Broe ME
Hum Toxicol (1984) 3: .
Buoyant, morphometric and functional alterations of lysosomes from proximal tubular cells during treatment with gentamicin.
Giurgea-Marion L, Laurent G, Heuson-Stiennon J, Beauchamp D, Tulkens P
Hum Toxicol (1984) 3: .
Effect of gentamicin treatment on the functional properties of lysosomes in rat kidney cortex.
Giurgea-Marion L, Laurent G, Toubeau G, Heuson-Stiennon J, Tulkens P
J Cell Biol (1984) 99:364A.
Animal study on the nephrotoxic potential of amikacin x ceftazidime combination at low doses.
Laurent G, Beauchamp D, Maldague P, Giurgea-Marion L, Tulkens PM
In: 24th Interscience Conference Antimicrobial Agents and Chemother., Washigton, DC, 478 (1984)
Gentamicin-induced stimulation of DNA synthesis in rat kidney cortex: correlation between in vivo and in vitro models..
Porter GA, Laurent G, Maldague P, Tulkens PM
In: IXth Intern. Congress of Nephrology, Los Angeles, Ca, (1984)
Aminoglycoside-induced alterations in distal and collecting tubules of rat kidney cortex.
Toubeau G, Laurent G, Heuson-Stiennon JA, Tulkens P
Biol Cell (1984) 52:98A.
Drug-induced phospholipidosis.
Tulkens P
In: 1st Mediterranean Congress of Therapy, Florence, Italy, (1984)
Conformational and biochemical studies of aminoglycoside-phospholipid interactions: a tool for the design of lesser toxic aminoglycosides.
Tulkens P, Brasseur R, Laurent G, Ruysschaert JM, Claes PJ, Vanderhaeghe HJ
In: 6th International Symposiuml on Future Trends in Chemotherapy, Pisa, Italy, 197 (1984)
Computer models and structure-activity relationship for the prediction of aminoglycoside nephrotoxicity..
Tulkens P, Ruysschaert JM, Brasseur R, Carlier MB, Laurent G, Claes JP, Vanderhaeghe HJ
In: 2nd Meeting on Nephrotoxicity (Nephrotox), Guildford (U.K.), (1984)
Polycationic gentamicin inhibits the tubular readsorption of plasma proteins according to their electric charge.
Viau C, Bernard A, Tulkens P, Lauwerys R
Hum Toxicol (1984) 3: .
Inhibition of lysosomal sphingomyelinase by incubation with negatively-charged phospholipid vesicles (liposomes).
Carlier MB, Ibrahim S, Laurent G, Tulkens P
In: 15th Meeting of the Federation of the European Biochemical Societies, Brussels, S-04FR054 (1983)
Analysis of kidney lysosomes by isopycnic centrifugation in a zonal rotor.
Giurgea-Marion L, Laurent G, Tulkens P
In: 15th Meeting of the Federation of the European Biochemical Societies, Brussels, Belgium, S-03MO031 (1983)
Molecular approach to the binding of gentamicin and amikacin to lipid bilayers containing phosphatidylinositol: a method to study the mechanism of aminoglycoside-induced phospholipidosis.
Laurent G, Brasseur R, Carlier MB, Ruysschaert JM, Tulkens P
Toxicol Lett (1983) 18(supl.1):133.
Combined in vitro and in vivo approach to compare the nephrotoxicity of aminoglycosides.
Laurent G, Brasseur R, Carlier MB, Toubeau G, Maldague P, Heuson-Stiennon J, Tulkens P
In: 23d Interscience Conference on Antimicrobial Agents and Chemotherapy, Las Vegas, Na, 590 (1983)
A combined experimental and mathematical approach to characterize aminoglycoside binding binding to lipid layers.
Laurent G, Brasseur R, Ruysschaert JM, Tulkens P
In: Meeting on Model Membranes (Belgium F.N.R.S. and Council of Europe), Brugge, (1983)
Evidence of tubular regeneration in rat kidney after short treatment with gentamicin at low doses.
Laurent G, Maldague P, Carlier MB, Tulkens P
In: 83d Annual Meeting of the American Society for Microbiology, New Orleans, La, A46 (1983)
Tubular regeneration in rat kidney after treatment with gentamicin at low doses.
Laurent G, Toubeau G, Maldague P, Carlier MB, Heuson-Stiennon J, Tulkens P
In: 24th Congress of the European Society of Toxicology, Rome, Italy, (1983)
S 86451, a 2'guanidyl derivative of gentamicin with reduced nephrotoxicity: studies at low and medium doses in the rat.
Maldague P, Laurent G, Carlier MB, Tulkens P
In: 24th Congress of the European Society of Toxicology, Rome, 40 (1983)
Dibekacin assay in serum by automated fluorescence polarization immunoassay: comparison with HPLC and substrate labelled fluorescent immunoassay.
Rollmann B, Van Der Auwera Ph, Yepsen R, Schwenzer K, Tulkens P
In: 23d Interscience Conference on Antimicrobial Agents and Chemotherapy, Las Vegas, Nevada, 107 (1983)
Régénération des tubes proximaux du cortex rénal de rat après traitement à la gentamicine.
Toubeau G, Laurent G, Maldague P, Carlier MB, Tulkens P, Heuson-Stiennon J
Biol Cell (1983) 48:42A.
Toxicity of aminoglycosides: recent insights and perspectives.
Tulkens P
In: 3d International Symposium on Nephrology (Kidney, Small Proteins and Drugs), Montecatini Terme, Italy, 58 (1983)
Aminoglycoside-induced renal phospholipidosis: in vitro demonstration of lysosomal phospholipases inhibition.
Carlier MB, Laurent G, Tulkens P
In: 22d Interscience Conference on Antimicrobial Agents and Chemotherapy, Miami, Fla, 47 (1982)
Influence of the dosage schedule on the accumulation and toxicity of gentamicin in rat kidney, at low dose (10 mg/kg).
Tulkens P, De Broe ME, Maldague P, Verpooten G, Scharpe S
In: 82d Annual Meeting of the American Society for Microbiology, Atlanta, Ga, 30 (1982)
S86451, a new derivative of gentamicin with reduced nephrotoxicity: biochemical, morphological and functional studies.
Wilmotte E, Maldague P, Tulkens P, Baumgartner R, Schmook F, Walzl H, Obenaus H
In: 5th International Symposium on Future Trends in Chemotherapy, Pisa, Italy, 51 (1982)
Gentamicin induces a loss of activity of acid phospholipase A in rat kidney cortex.
Carlier MB, Tulkens P
Arch Int Physiol Biochim (1981) 89:B5-B6.
Early toxic events in kidney of rat and man following administration of gentamicin at low doses.
Carlier MB, Paulus G, Maldague P, Giurgea L, Wilmotte E, De Broe ME, Tulkens P
In: 22d Congress of the European Society of Toxicology, Dublin, 17-19 August 1981, 46 (1981)
Uptake and intracellular distribution of penicillin V, ampicillin and cephalexin in macrophages.
Carlier MB, Trouet A, Tulkens P
In: 81st Annual Meeting of the American Society of Microbiology, Dallas, Tx, A21 (1981)
Comparative nephrotoxicity of gentamicin, netilmicin, tobramycin and amikacin.
Morin JP, Ollier B, Viotte G, Tulkens P, Van Hoof F, Fillastre JP
In: 12th Intern.Congress of Chemotherapy, Florence, Italy, 709 (1981)
Prospective study of gentamicin nephrotoxicity in the human kidney.
Paulus G, Verpooten G, Rutsaert R, Tulkens P, Roels F, De Broe ME
Kidney Int (1981) 20:432.
Comparative study of the lysosomal alterations induced in kidney of rat and man by aminoglycosides at low doses.
Paulus G, Wilmotte E, Maldague P, Carlier MB, Verpooten G, Scharpe P, Tulkens P
In: 21st Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, Ill, 543 (1981)
Mechanism of toxicity of gentamicin in rat kidney and comparisons with amikacin and tobramycin.
Tulkens P, Carlier MB, Beauwens R, Maldague P, Morin JP, Van Hoof F
In: 12th Intern. Congress of Chemotherapy, Florence, Italy, 1086 (1981)
Nephrotoxicity of aminoglycosides in humans. A prospective and comparative study.
Verpooten GA, Paulus G, Tulkens P, Van Hoof F, Roels F, De Broe ME
In: 12th Intern. Congress of Chemotherapy, Florence, July 19-24, 1981, 1093 (1981)
Aminoglycoside antibiotics inhibit the normal antidiuretic hormne response.
Beauwens R, Rentmeesters M, Van Hoof F, Tulkens P
Eur J Clin Invest (1980) 10:3.
Nephrotoxicity of gentamicin in the human kidney.
De Broe ME, Verpooten GA, Rutsaert R, Paulus G, Van Hoof F, Tulkens P, Zachee R
Kidney Int (1980) 18:136.
Biochemical and ultrastructural alterations induced in the lysosomes of rat kidney cortex by two aminoglycoside antibiotics : gentamicin and amikacin.
Morin JP, Van Hoof F, Tulkens P
Arch Int Physiol Biochim (1980) 88:B93-B94.
Cellular toxicity of gentamicin in kidney of rat, rabbit and man.
Tulkens P, Hjelle JT, Morin JP, De Broe ME, Carlier MB, Van Hoof F
In: 20th Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, La, 555 (1980)
Use of a model of cultured cells for comparative studies of the ellular toxicity of aminoglycosides (gentamicin, tobramycin and amikacin).
Tulkens P, Morin JP, Carlier MB, Van Hoof F
In: Workshop on the Application of Tissue Culture in Toxicology, Soesterberg, The Netherlands, (1980)
Toxicity of aminoglycoside antibiotics: gentamicin, tobramycin and amikacin in cultured cells and in kidney.
Tulkens P, Van Hoof F, Morin JP, Hjelle JT, Carlier MB, De Broe ME, de Barsy Th
Toxicol Lett (1980) SI.1:119.
Comparative toxcity of three aminoglycoside antibiotics : gentamicin, amikacin and streptomycin, towards the lysosomes of cultured cells.
Van Hoof F, Morin JP, Tulkens P
Arch Int Physiol Biochim (1980) 88:B112-B114.
Recycling of cell surface membrane during endocytosis.
Tulkens P, Trouet A
Adv Exp Med Biol (1979) 114:413-414.
Intracellular distribution of two non-steroidal anti-inflammatory drugs : indomethacin and ketoprofen, in cultured fibroblasts.
Blanchard JC, Schneider Y-J, Tulkens P, Trouet A
In: 7th International Congress of Pharmacology, Paris, France, (1978)
Cellular pharmacology: a tool for the evaluation and development of drugs.
Tulkens P
In: 3rd Intern. Meeting of Pharmaceutical Physicians, Brussels, Belgium, Acta Therapeutica, Pub., 94 (1978)
Cellular uptake and subcellular distribution of anti-inflammatory drugs: chloroquine, indomethacin and ketoprofen.
Tulkens P, Blanchard JC, Schneider Y-J, Trouet A
In: Compte-rendus des groupes de contact du F.R.S.M., Bruxelles, Belgique, (1978)
Cell surface and lysosome membranes: functional and structural relationships.
Tulkens P, Schneider Y-J, Trouet A
In: Interdisciplinary Training Course: Structure and Functions of Biological Membranes: Molecular Aspect, Comission of the European Communities and Centre de Biophysique Mol{culaire (C.N.R.S., France), A23-A24 (1978)
Production of rabbit anti-rat cathepsin B antibodies.
Piérart-Gallois M, Trouet A, Tulkens P
In: 3d Symp. on Intracellular Protein Catabolism, Lubljana, Yougoslavia, Martin Luther Universität, Halle-Wittenberg, Wissenschafliches Beiträge, Halle (Saale), 27 (1977)
A shuttle between cell membrane and lysosomes during endocytosis.
Tulkens P, Schneider Y-J, Trouet A
In: Symposium on Protein Turn-Over and Lysosomal Function, State University of New York at Buffalo, 47-48 (1977)
Flow, recycling and turn-over of plasma membrane constituents during endocytosis.
Tulkens P, Schneider Y-J, Trouet A
In: 3d Symp. on Intracel.Protein Catabolism, Lubljana, Yougoslavia, Martin Luther Universität, Halle-Wittenberg, Wissenschafliche Beiträge, Halle (Saale), 37-39 (1977)
Accumulation and localization of neutral red in cultured fibroblasts.
Bulychev A, Trouet A, Tulkens P
Arch Int Physiol Biochim (1976) 84:1055-1056.
Uptake and intracellular localization of morphine in lysosomes and cell sap of cultured fibroblasts.
Liesse M, Lhoest G, Trouet A, Tulkens P
Arch Int Physiol Biochim (1976) 84:638-639.
Uptake and localization of cathepsin D and of antibodies, directed against lysosomes of cathepsin D in cultured fibroblasts.
Schneider Y-J, Tulkens P, Trouet A
Arch Int Physiol Biochim (1976) 84:655-657.
Studies on the mechanism and regulation of endocytosis in fibroblasts by means of antibodies.
Schneider Y-J, Tulkens P, Trouet A
J Cell Biol (1976) 70:323a.
Studies on the mechanism and regulation of endocytosis in fibroblasts.
Tulkens P, Schneider Y-J, Trouet A
In: Symposium on Endocytosis and Intracellular Digestion, British Society for Cell Biology, (1976)
Biochemical characterization of lysosomes and plasma membrane of cultured leukemic L1210 cells.
Zenebergh A, Loni MC, Tulkens P, Trouet A
Arch Int Physiol Biochim (1976) 84:684-685.
Purification and antigenic characterization of plasma membrane from hepatoma cells in culture (HTC cells).
Sauvage Ph, Trouet A, Tulkens P
Arch Int Physiol Biochim (1975) 83:995-996.
Uptake and intracellular fate of antiplasma membrane antibodies in cultured fibroblasts.
Schneider Y-J, Trouet A, Tulkens P
Hoppe Seyler's Z Physiol Chem (1975) 335:84.
Intracellular fate of plasma membrane antigens during endocytosis.
Schneider Y-J, Trouet A, Tulkens P
Arch Int Physiol Biochim (1975) 83:997-998.
Studies on endocytosis in fibroblasts with the use of specific antibodies.
Tulkens P, Schneider Y-J, Trouet A
In: 2d Intern. Symposium Intracellular Protein Catabolism, Union of the Chemical Societies of Yugoslavia, Ljubljana ed., 69-70 (1975)
Lysosome overloading and dysfunction induced by streptomycin in cultured fibroblasts.
Tulkens P, Van Hoof F, Trouet A
Arch Int Physiol Biochim (1975) 83:1004-1006.
Uptake and intracellular localization of kanamycin and gentamicin in the lysosomes of cultured fibroblasts.
Tulkens P, Trouet A
Arch Int Physiol Biochim (1974) 82:1018-1019.
Characterization of subcellular constituents of hepatoma cultured celles (HTC cells).
Lopez-Saura P, Tulkens P, Trouet A
Arch Int Physiol Biochim (1972) 80:977-978.
Uptake and intracellular localization of streptomycin in the lysosomes of cultured fibroblasts.
Tulkens P, Trouet A
Arch Int Physiol Biochim (1972) 80:623-624.
Influence of the injection of some sugar solutions on the properties of rat liver lysosomes.
Wattiaux R, Wattiaux-De Coninck S, Tulkens P, Koninckx Ph
In: 2d Meeting of the Federation of the European Societies of Biochemistry, Vienna, Austria, A-181 (1965)

Last update: 22/01/2001
Corrections and additions: <tulkens@facm.ucl.ac.be>