PPT Slide
Resistance to erythromycin confers cross-resistance to all other macrolides
except telithromycin
Resistance to macrolide antimicrobials
- Target modification (MLSB resistance):
- methylation of rRNA blocks drug binding
- methylase encoded for by plasmid-borne erm genes
- confers resistance to all macrolides, streptogramins and lincosamides
- inducible or constitutive
- Efflux (M-resistance):
- confers resistance to other macrolides but not other members of MLS group