PPT Slide
Fluoroquinolone resistance
- Anti-pneumococcal in vitro activity and AUIC: moxifloxacin > levofloxacin
- Weaker fluoroquinolones may lead to more rapid emergence of resistance
- Reports of treatment failure and resistance development with levofloxacin (NEJM 2002;346:747)
- When a fluoroquinolone is indicated: use the most potent agent