PPT Slide

DOSE (mg)

MIC

90

(mcg/ml)

Peak/MIC

AUC/MIC

LFX

500

1

-

2

3

-

6

24

-

48

MOX

400

0.

125

-

0.25

9

-

18

96

-

192

PK/PD of levofloxacin and moxifloxacin  vs. S. pneumoniae

JAC 2000;46:669

AUIC (AUC/MIC) minimal for successful outcome = 35 - 40 (minimal)

High Peak/MIC: also important for prevention of resistance selection

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