GLYCOPEPTIDE ANTIBIOTICS


from Old Mississipi mud …


  … to molecular mechanisms:

Glycopeptide story:
 from natural to semi-synthetic derivatives

vancomycine - téicoplanine

Peptidoglycan synthesis

Glycopeptide mechanism of action

Binding of vancomycin to D-Ala-D-Ala

Resistance in enterococci

Resistance in enterococci

Resistance in staphylococci (GISA)

Resistance in staphylococci (GISA)

Resistance in staphylococci (GRSA)