Zwick et al, Trends in Molecular Medicine (2002) 8: 17-23
MONOCLONAL ANTIBODIES AS ANTI-
TYROSINE KINASE RECEPTOR
DRUGS
Anti-RTK mAbs block the
ligand-receptor interaction
ð
inhibition of ligand-induced
RTK signaling
ð
increase of RTK down
regulation and internalization
2003-2004