2/11/2004
FARM 2147 Fluoroquinolones
9
From chloroquine to nalidixic acid...
nalidixic acid
N
HN
Cl
N
CH
3
CH
3
chloroquine
1939
1958
1962
N
C
O
C
2
H
5
O
-
O
Cl
N
N
C
O
O
-
H
3
C
O
C
2
H
5
7-chloroquinoline
(synthesis intermediate
found to display
antibacterial activity)