2/11/2004
FARM2147
13
Drug interactions with macrolides
•The main problem due to interactions between some macrolides and the cytochrome P 450 system, especially the CYP3A subclass of enzymes
•Finally results in lowered metabolism of CYP3A-dependent drugs
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•drug azi clari diri ery josa mid roxi spira
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•thιophyllin 0 0 0 ++ + ND 0/+          0
•ciclosporin ND ND ND +++ +++ +++ + 0
•carbamazepin ND 0/+ ND +++ + + 0/+ 0/+
•midazolam 0 ++ ND ++ ND ND + ND
•warfarin 0 ND ND + ND ND 0 ND
•terfenadin 0 ++ ND +++ 0/+ ND 0 ND
•cisapride ND ++ ND ++ ++ ND ND 0
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•From Petitjean et al. N=undocumented •Mainly considered as a class-effect, resulting from what is known for erythromycin, except for spira and azithromycin
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