2/11/2004
FARM 2147 Fluoroquinolones
42
How to apply this ?
Levofloxacin  500 mg
  1X /day
AUC [(mg/l)xh]    47
• peak [mg/l]          5
* MICmax       < 0.5
Moxifloxacin  400 mg
   1X/day
• AUC [(mg/l)xh]   48
• peak [mg/l]           4.5
* MICmax               < 0.5
0
20
40
60
80
100
0.015
0.03
0.06
0.125
0.25
0.5
1
2
4
MIC
    % of sensitive strains
levo
moxi
MIC data: J. Verhaegen et al., 2001
2X /day
94
  5
< 1