2/11/2004
FARM 2147 Fluoroquinolones
nalidixic
acid
1. modify naphthyridone
into quinolone
oxolinic
acid *
From nalidixic acid to the
1st fluoroquinolone (1 of 4)
N
C
O
O
-
O
C
2
H
5
O
O
N
N
C
O
C
2
H
5
O
-
O
H
3
C
shows
reduced protein binding...
*
quinoleine
* Ger. pat. to Warner Lambert, 1967