Zwick et al, Trends in Molecular Medicine (2002) 8: 17-23
RECEPTOR TYROSINE KINASE-
INTRACELLULAR BINDING SITE
Catalyse of recepteur autophosphorylation of cytoplasmic
tyrosine residues
àDocking sites for Src homology (SH) and phosphotyrosine-binding (PTB) containing molecules (PLC, Src, …)
Recrutment of additional effectors molecules containing SH2, SH3, PTB,PH (pleckstrin) domain
ðActivation of a cascade of intracellular biochemical signals
2003-2004