12-Feb-04
Glycopeptides (FARM 2146)
2
Glycopeptide story:
 from natural to semi-synthetic derivatives
~ 1950 :
discovery of vancomycin in Mississipi mud
~ 1985 :
large clinical use in USA
Gram(+) infections and digestive tract decontamination
Problem:
Ø  toxicity of vancomycin due to impurities 
     è better purification procedures
~ 1980 :
discovery of teicoplanin, as a natural GP with improved PK
§  largely used in Europe