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Glycopeptide
story:
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from natural
to semi-synthetic derivatives
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~ 1950 :
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discovery of
vancomycin in Mississipi mud
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~ 1985 :
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large clinical
use in USA
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Gram(+)
infections and digestive tract decontamination
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Problem:
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toxicity of vancomycin due to impurities
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è better purification
procedures
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