Is there a SAR for emergence of resistance ?
Bactericidal activity of FQs against
Mycobaterium bovis
MIC
(99)
1
-2
R
-4
PD160793
PD161148
-6
MPC
(10)
R =
OCH
3
R =
H
-8
MIC
99
0.25
0.8
-10
MPC
10
0.9
9
MPC/MIC
3.6
12
0.01
0.10
1.00
10.00
FQ concentration
29