• 41 amino acid neuropeptide
•
• Initiates the hypothalamic-pituitary-adrenal
axis
response to stress
• Four CRF-related peptides
•
• Two G-protein-coupled CRF receptor subtypes
(CRF 1/2)
•
• CRF1 receptor antagonists might be capable
of blocking pathological
CRF-mediated stress responses without producing unwanted side effects caused
by a general suppression
of hypothalamic-pituitary-adrenal axis activity