2/11/2004
FARM 2147 Fluoroquinolones

0.01
0.10
1.00
10.00
10
-2
1
FQ
concentration
Fraction of survivors
10
-4
10
-6
10
-8
10
-10

MIC (99)
MPC (10)

R = H
R = OCH3
N
C
O
F
N
O
-
O
CH
3
HN
H
5
C
2
R
MIC 99 0.25 0.8
MPC 10 0.9 9
MPC/MIC 3.6 12
Dong et al; AAC
43:1756-1758
Bactericidal activity of FQs against
Mycobaterium bovis
Is there a SAR for emergence of resistance ?





PD160793 PD161148