NEUROPEPTIDE Y
 Abundantly expressed in numerous brain areas,
including the locus coerulus, hypothalamus, amygdala,
hippocampus, nucleus accumbens, and neocortes
 colocalizes with noradrenaline, GABA
 Actions mediated through heterogeneous G-protein
coupled receptors, among which Y1, Y2 and Y5 receptor
subtypes mediate CNS effects
 Y1 and Y5 receptorr activation is anxiolytic
 Y2 receptor activation is anxiogenic like
FARM 2146 - 2003-2004