2/11/2004
FARM 2147
Fluoroquinolones
4
•
Ternary complex
DNA - enzyme - fluoroquinolone
DNA GYRASE
catalytic subunits
DNA GYRASE
ATP binding subunits
COVALENTLY CLOSED
CIRCULAR DNA
FLUOROQUINOLONES:
4 stacked molecules
Cabral
et al.,
Nature, 1997