2/11/2004
FARM2147
29
Pharmacokinetics of telithromycin
(as submitted to the FDA; april 2001)
http://www.fda.gov/ohrms/dockets/ac/01/slides/3746s_09_aventis/
800 mg
800 mg
(single dose)
(7 days)
C
max
(mg/L)
1.9 (42)
2.3 (31)
C
24h
(mg/L)
0.03 (45)
0.07 (72)
AUC
24h
(mgxh/L)
8.3 (31)
12.5 (43)
t
1/2
(h)
7.2 (39)
9.8 (20)
The company has declared
that activity of telithromycin is
driven by C
max
/MIC and by
AUC
24h
/MIC ratios