2/11/2004
FARM 2147 Fluoroquinolones
38
SAR of main pharmacokinetic parameters:
how to get a long half life
t 1/2 (h)      no. of daily
         administrations
oflo / lévo    5 - 7    2 x*
peflo 10    2 x*
flero   9 - 13    1 x
grepa 10 - 12    1 x
gati 13    1 x
gemi   8    1 x
trova 10    1 x
moxi 12    1 x
other FQ    3 - 6    2 x
* higher MIC...
N
HN
H
3
C
H
3
C
N
N
N
H
H
H
3
N
+
HN
N
N
CH
2
N
H
3
CO
H
2
N