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The "Mutant
Prevention Concentration" *
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"When
Mycobacterium bovis BCG and Staphylococcus aureus were
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plated on agar
containing increasing concentrations of fluoroquinolone,
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colony
numbers exhibited a sharp drop, followed by a plateau and a second
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sharp drop.
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The plateau region correlated,vith the
presence of first-step resistant
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mutants.
Mutants were not recovered at concentrations above those
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required for
the second sharp drop, thereby defining a mutant prevention
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concentration
(MPC).
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A C8-methoxy group lowered the MPC for an N-1-cyclopropyl
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fluoroquinolone"
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