• Abundantly expressed in numerous brain areas, including the locus coerulus,
hypothalamus, amygdala, hippocampus,
nucleus accumbens, and neocortes
•
• colocalizes with noradrenaline, GABA
•
• Actions mediated through heterogeneous
G-protein coupled
receptors, among which Y1, Y2 and Y5 receptor subtypes mediate CNS effects
•
• Y1 and Y5 receptorr activation is
anxiolytic
• Y2 receptor activation is anxiogenic like