2/11/2004
FARM 2147 Fluoroquinolones
N
C
O
F
O
-
O
HN
N
-
H
3
C

N
C
O
O
-
O
HN
N
N
C
O
O
-
O
N
N

CH
3
CH
3
F
F
norfloxacin
ciprofloxacin
*
pefloxacin
cyclopropyl to
increase potency
* Ger. pat.
3,142,854 to Bayer AG, 1983
O
CH
3
-
H
3
C
N
C
O
O
-
O
N
N

F
ofloxacin
From norfloxacin to the other 1st generation fluoroquinolones:
ciprofloxacin