 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
|
|
The present "first generation" of
fluoroquinolones ...
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
• |
Norfloxacin
|
|
|
|
|
 |
 |
• |
Nalidixic acid
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
• |
Pefloxacin
|
|
|
|
|
|
 |
 |
• |
Oxolinic acid
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
• |
Ofloxacin
|
|
|
|
|
|
 |
 |
• |
Flumequine
|
|
|
|
|
|
|
|
|
|
 |
 |
improved
|
|
anti Gram (-)
|
activity
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
• |
Pipemidic acid
|
|
|
 |
 |
• |
Ciprofloxacin
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
• |
Fleroxacin
|
|
|
|
|
|
|
|
|
|
|
 |
 |
• |
Rufloxacin
|
|
|
|
|
|
|
|
|
|
|
 |
 |
• |
Levofloxacin
|
|
|
|
|
|
|
|
 |
 |
 |
 |
|
twice
|
|
|
|
as
active as
|
|
ofloxacin
per g
|
|
|
|
|
 |
|
 |
|
|
|
|
|
|
|
|
|
|