 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
|
|
 |
 |
 |
 |
|
IMMUNOTOXIN CONJUGATES AND LIGAND
|
|
|
BINDING CYTOTOXIC AGENTS TO INHIBIT THE
|
|
|
RECEPTOR
TYROSINE KINASE SIGNALING
|
|
|
|
|
|
 |
|
|
|
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
• |
Fusion/conjugaison
|
|
|
between
immunotoxins and
|
|
specific ligand
|
|
|
• |
Binding to cell surface
|
|
|
receptors
|
|
|
• |
Internalization
into the
|
|
|
endosome and
translocation
|
|
to the cytosol
|
|
|
• |
Inhibition of
protein
|
|
|
synthesis
|
|
|
|
|
|
 |
|
|
|
|
|
Zwick et al, Trends in
Molecular Medicine (2002) 8: 17-23
|
|
|
 |
|