NEUROPEPTIDE Y
• Abundantly expressed in numerous brain areas, including the locus coerulus, hypothalamus, amygdala, hippocampus, nucleus accumbens, and neocortes
•
• colocalizes with noradrenaline, GABA
•
• Actions mediated through heterogeneous G-protein coupled receptors, among which Y1, Y2 and Y5 receptor subtypes mediate CNS effects
•
• Y1 and Y5 receptorr activation is anxiolytic
• Y2 receptor activation is anxiogenic like
FARM 2146 - 2003-2004