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Erythromycin: mode of action

Erythromycin: mode of action

Erythromycin: spectrum of activity

Slide 6

Erythromycin: the problems

Erythromycin: details of
acid the degradation

What have the chemists done to
avoid acid-instability ?

What have the chemists done to
avoid acid-instability ?

Did these modifications change
anything else in PK ?

Did these modifications change
anything else ?

Drug interactions with macrolides

Basic indications of (classical) macrolides
in a world of no resistance

Which is the best ?

But was has been the problem ?

Slide 17

Slide 18

Slide 19

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Slide 21

Slide 22

Inhibition of Protein Synthesis (1)

Telithromycin

Resistance: a semi-rational answer ...

Inhibition of Protein Synthesis (2)

MIC50 [µg/ml] of wild type and mutant strains

Telithromycin

Pharmacokinetics of telithromycin
(as submitted to the FDA; april 2001)

Pharmacodynamics of telithromycin
(as based on FDA submission; april 2001)

Which are the sensivities of S. pneumoniae towards telithromycin in Belgium in 2000 ?

Macrolides: the 16 atoms family

Macrolides: the 16 atoms family

Properties of the 16 atoms family

Macrolides: the present family picture