TARGETS FOR DRUG ACTION
Ions-channels
Ion channels
Blockers
Modulators
Voltage-gated sodium
channels
Local anaesthetics
Tetrodotoxin
Veratridine
Renal tubule sodium
channels
Amiloride
Aldosterone
Voltage-gated calcium
channels
Divalent cations
Dihydropyridines
b-adrenoreceptor
agonists
Voltage-gated
potassium channels
4-aminopyridine
Many neuromodulators
ATP-sensitive
potassium channels
ATP
Cromokalim
Sulphonylureas
GABA-gated chloride
channels
Picrotoxin
Benzodiazepines
Glutamate-gated
(NMDA) cation
channels
Dizocilpine, Mg 2+ ,
Ketamine
Glycine
2003-2004