Is there a SAR for emergence of resistance ?
Bactericidal activity of FQs against Mycobaterium bovis
MIC (99)
1
-2
Text Box: Fraction of survivors
R
-4
PD160793     PD161148
-6
MPC (10)
R = OCH3
R = H
-8
MIC 99          0.25          0.8
-10
MPC 10        0.9             9
MPC/MIC     3.6           12
0.01
0.10
1.00
10.00
FQ concentration
29