Telithromycin
Telithromycin, the first ketolide, was designed to
overcome erythromycin A resistance within Gram (+)
positive cocci and take advantage of PK improvements of
clarithromycin
Side chain for
improved
activity
To avoid chemical
instability
O
R
OCH3
9
N
6
O
D - desosamine
11
O
12
O
3
O
New chemical
class (3–keto)
active against ermR
C11–C12 carbamate
for anchoring
O
O
FARM2147
2/11/2004