SUBSTANCE  P
Caracterization
• 11 amino acid peptide belonging to the tachykinin family
• Mediates its biological activity through G-protein-coupled
tachykinin receptors
•
Neuropeptide receptor targets for stress-related disorders
NK1 receptor antagonists
MK0869 Aprepritant (phase III clinical trials)
NK2 receptor antagonists
Holmes et al, TIPS, 24:580-588 (2003)
FARM 2146 - 2003-2004