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A
protonated H+-sensor stabilizes
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the
NR1-NR2B heterodimer in low-
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conductance
state
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Polyamines
(spermine, spermidine)
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shield
the H+-sensor from protons
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thus
attenuating the inhibition by
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proton and potentialising the influx
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of Ca 2+
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Ifenprodil
enhances the sensitivity
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to
protons
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From Chizh et al. TiPS 22: 636-642 (2001)
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