PBP …
X-ray structure of PBP2x
from Streptococcus
pneumoniae (Protein
data bank accession
code 1QMF). The
antibiotic cefuroxime is
harbored in the
transpeptidase domain,
whose cleft is
reminiscent of class A b-
lactamases. The N-
terminal domain region
may contact other
macromolecules in the
“divisome” complex.
6