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• |
Telithromycin,
the first ketolide, was designed to
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overcome
erythromycin A resistance within Gram (+)
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positive cocci
and take advantage of PK improvements of
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clarithromycin
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Side chain for
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improved
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activity
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To avoid chemical
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instability
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New chemical
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class (3–keto)
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active against ermR
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C11–C12
carbamate
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for anchoring
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