2/11/2004
FARM 2147 Fluoroquinolones
SAR of main
pharmacokinetic parameters:
how to get a long half life
t 1/2 (h) no. of
daily
administrations
oflo / lévo
5 - 7 2 x*
peflo 10 2 x*
flero
9 - 13 1 x
grepa 10 - 12 1 x
gati 13 1 x
gemi
8 1 x
trova 10 1 x
moxi 12 1 x
other FQ 3 - 6 2 x
* higher
MIC...
N
HN
H
3
C
H
3
C


N
N



N
H
H
H
3
N
+


HN
N
N
CH
2
N
H
3
CO
H
2
N





