Agonist binding site is located in the large N-terminal extracellular
domain which
is connected to the seven-transmembrane G-protein-coupled receptor by a cysteine rich
linker
Residues within
intracellular loops 2 and 3 appear to be crucial for G-protein coupling selectivity and activation
C-terminal tail contains
residues that are involved in the protein kinase C-induced desensitization of the receptor and in the interaction
with intracellular
proteins
RECEPTEURS METABOTROPIQUES
AU GLUTAMATE
FARM 2146 - 2003-2004
ECB: Extracellular
domain
LB: ligand binding
lobes
AM: allosteric modulators
Pelligrini-Giampietro et al, TiPS (2003) 24 461-470