2/11/2004
FARM2147
Inhibition of Protein Synthesis (2)
•Inhibition of peptidyl
transferase activity
5S rRNA
Domain V
Domain II
Pocket: peptidyl transferase site
5S rRNA
5S rRNA
2058
752
V
II
V
II
Erythromycin A
Telithromycin

2058
752




30S
50S



O
O
O


O
O
O

-cladinose
erm
From
Bryskier,
FDA
presentation of KETEK®
mef