2/11/2004
FARM2147
29
Pharmacokinetics of telithromycin
(as submitted to the FDA; april 2001)
http://www.fda.gov/ohrms/dockets/ac/01/slides/3746s_09_aventis/
                    800 mg 800 mg
                 (single dose) (7 days)
Cmax (mg/L) 1.9 (42) 2.3 (31)
C24h (mg/L) 0.03 (45) 0.07 (72)
AUC24h (mgxh/L) 8.3 (31) 12.5 (43)
t 1/2 (h) 7.2 (39) 9.8 (20)
The company has declared that activity of telithromycin is driven by Cmax/MIC and by AUC24h/MIC ratios