Zwick et al, Trends in Molecular Medicine (2002) 8: 17-23
IMMUNOTOXIN CONJUGATES AND LIGAND BINDING CYTOTOXIC AGENTS TO INHIBIT THE RECEPTOR TYROSINE KINASE SIGNALING
• Fusion/conjugaison   between immunotoxins and specific ligand
•
• Binding to cell surface receptors
•
•Internalization into the endosome and translocation to the cytosol
•
•Inhibition of protein synthesis
2003-2004