NEUROPEPTIDE SYSTEMS AS NOVEL
THERAPEUTIC TARGETS FOR DEPRESSION
AND ANXIETY DISORDERS
Neuropeptides demonstrate important functional
interactions with monoamines but their effects go
beyond modulation of these neurotransmitters
Neuropeptides possess a more discrete
neuroanatomical localization than monoamines and
GABA, and thus might be expected to produce relatively
little disruption of normal physiology
Neuronal release of neuropeptides requires higher
stimulation frequencies than that required by
monoamine transmitters colocalized in the same neuron
FARM 2146 - 2003-2004