2/11/2004
FARM 2147 Fluoroquinolones
How to
apply this ?
Levofloxacin 500 mg
1X /day
AUC [(mg/l)xh] 47
• peak [mg/l] 5
* MICmax < 0.5
Moxifloxacin 400 mg
1X/day
• AUC [(mg/l)xh] 48
• peak [mg/l] 4.5
* MICmax
< 0.5
0
20
40
60
80
100
0.015
0.03
0.06
0.125
0.25
0.5
1
2
4
MIC
% of sensitive strains
levo
moxi
MIC data:
J. Verhaegen et al., 2001