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Ubiquitin act as
a sorting signal in early endosomes
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àconjugation with ubiquitin = means to
terminate
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signalling by rapid downregulation of
receptors at
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the plasma membrane
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Plic proteins
interfere with the degradation of ubiquitin-
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substrates à ä T1/2
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T1/2
of GABA receptors ä by binding of the receptor to Plic
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ðModulation of the surface expression of GABA receptors
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ðRapid adaptation of neural excitability
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