Erythromycin: spectrum of activity
Erythromycin: details of
acid the degradation
What have the chemists
done to
avoid acid-instability ?
What have the chemists
done to
avoid acid-instability ?
Did these modifications
change
anything else in PK ?
Did these modifications
change
anything else ?
Drug interactions with macrolides
Basic indications of
(classical) macrolides
in a world of no resistance
But was has been the problem ?
Inhibition of Protein Synthesis (1)
Resistance: a semi-rational answer ...
Inhibition of Protein Synthesis (2)
MIC50 [µg/ml] of wild type and mutant strains
Pharmacokinetics of
telithromycin
(as submitted to the FDA; april 2001)
Pharmacodynamics of
telithromycin
(as based on FDA submission; april 2001)
Which are the sensivities of S. pneumoniae towards telithromycin in Belgium in 2000 ?
Macrolides: the 16 atoms family
Macrolides: the 16 atoms family