NEUROPEPTIDE
SYSTEMS AS NOVEL THERAPEUTIC TARGETS FOR DEPRESSION AND
ANXIETY DISORDERS
Neuropeptides
demonstrate important functional interactions
with monoamines but their effects go beyond modulation of these neurotransmitters
Neuropeptides possess a more discrete neuroanatomical localization than monoamines and GABA, and thus might be expected to produce
relatively little
disruption of normal physiology
Neuronal release of neuropeptides
requires higher stimulation
frequencies than that required by monoamine transmitters colocalized in the same
neuron
FARM 2146 - 2003-2004