From nalidixic acid to the
1st fluoroquinolone
(1 of 4)
nalidixic acid
flumequine *
2. discovery of
flumequine *
O
O
O
O
F
C
C
-
-
N
C
N
N
5
3
shows weak but broad
Gram(-) activity
* Ger pat. to Rikker Labs, 1973
* benzo-quinolizine
12