2/11/2004
FARM 2147 Fluoroquinolones
10
Nalidixic acid *
* Belg.  pat. 612,258 to Sterling Drugs, 1962
-
• typical chemical features of
fluoroquinolones (a, b, c)
   BUT a naphthridone
 (N at position 8:    )
• limited usefulness as drug
• narrow antibacterial spectrum
(Enterobacteriaceae only)
• short half-life (1.5h)
• high protein binding (90%)
a
b
c
N
N
C
O
C
2
H
5
O
-
O
H
3
C