2/11/2004
FARM2147
Inhibition of Protein Synthesis (1)
•Inhibition of peptidyl
transferase activity
5S rRNA
Domain V
Domain II
Pocket: peptidyl transferase site
5S rRNA
V
II
Erythromycin A
2058
752


30S
50S


O
O
O


-cladinose
erm
Modified
from Bryskier
(FDA
presentation of KETEK®)
mef