The “second generation” fluoroquinolones
1970
1980
1990
2000
1960
 Temafloxacin a
 Gram (-);

 improved
  Gram (+)
 Sparfloxacin b
 Grepafloxacin c
  Gatifloxacin d
anti-anaerobe
a: Toyama, 1988 (?) ; b: Dainippon, 1985-1987; c: Otskuda, 1989; d: Kyorin, 1988
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