2003
Antifongiques
Inhibiteurs
de la 14- a-déméthylase
miconazole (3/4)
CH
3


Cl
N
O
N
Cl
Cl
Cl
lanostérol
Recent
data: cell growth arrest
correlates with the accumulation of 14a-methyl-ergosta-8,24(28)-dien-3b,6a-diol in a yeast strain with a sterol 14a-demethylase gene disruption, which mimics stringent
treatment conditions (Kelly et al., B.B.A.,
1995, 207:910-915.
inhibition par
recouvrement du
substrat ??