TARGETS FOR DRUG ACTION
Ions-channels
Glycine
Dizocilpine, Mg 2+ , Ketamine
Glutamate-gated (NMDA) cation channels
Benzodiazepines
Picrotoxin
GABA-gated chloride channels
Cromokalim
Sulphonylureas
ATP
ATP-sensitive potassium channels
Many neuromodulators
4-aminopyridine
Voltage-gated potassium channels
Dihydropyridines
b-adrenoreceptor agonists
Divalent cations
Voltage-gated calcium channels
Aldosterone
Amiloride
Renal tubule sodium channels
Veratridine
Local anaesthetics
Tetrodotoxin
Voltage-gated sodium channels
Modulators
Blockers
Ion channels
From Pharmacology- Ed Rang et al (2003)-Churchill Livingstone, p 24
2003-2004