2/11/2004
FARM 2147
Fluoroquinolones
33
SAR of frequent side effects
N
X
8
COO
-
O
R
5
F
R
7
R
1
Phototoxicity
C
F
Inhibition of P450
Inhibition of P450
N
Binding to
GABA receptor
Penetration
in CNS
HN
N
R
HN
N
R
R
R
sparflo,
flero,
lomeflo
Ca
++
, Al
+++
, Fe
++
complexation
cipro,
grepa ...
All FQs