From nalidixic acid to the
1st fluoroquinolone (1 of 4)
nalidixic acid
oxolinic acid *
1. modify naphthyridone
    into quinolone
O
O
O
O
C
C
O
-
-
O
C
N
N
N
5
5
shows reduced protein binding...
* Ger. pat. to Warner Lambert, 1967
* quinoleine
11