Notes
Outline
GLYCOPEPTIDE ANTIBIOTICS
from Old Mississipi mud …
… to molecular mechanisms:
Glycopeptide story:
from natural to semi-synthetic derivatives
vancomycine - téicoplanine
Peptidoglycan synthesis
Glycopeptide mechanism of action
Binding of vancomycin to D-Ala-D-Ala
Resistance in enterococci
Resistance in enterococci
Resistance in staphylococci (GISA)
Resistance in staphylococci (GISA)
Resistance in staphylococci (GRSA)