2/11/2004
FARM2147
26
Inhibition of Protein Synthesis (2)
•Inhibition of peptidyl transferase activity
5S rRNA
Domain V
Domain II
Pocket: peptidyl transferase site
5S rRNA
5S rRNA
2058
752
V
II
V
II
Erythromycin A
Telithromycin
2058
752
30S
50S
O
O
O
O
O
O
-cladinose
erm
From Bryskier,
FDA presentation of KETEK®
mef