2/11/2004
FARM 2147 Fluoroquinolones
11
nalidixic acid
1. modify naphthyridone
    into quinolone
oxolinic acid *
From nalidixic acid to the
1st fluoroquinolone (1 of 4)
N
C
O
O
-
O
C
2
H
5
O
O
N
N
C
O
C
2
H
5
O
-
O
H
3
C
shows reduced protein binding...
* quinoleine
* Ger. pat. to Warner Lambert, 1967