The carbamylated
enzyme only slowly
hydrolyzes
 Phenserine is
further stabilized by
both hydrophobic
and p electron
interaction due to p-p
stacking of the
phenyl group of
phenylcarbamate
between the flanking
phenyl moieties of
Phe 295 and Phe 297
Yu et al 2001, J.Med.Chem. 44:4062-407