2/11/2004
FARM2147
30
Pharmacodynamics of telithromycin
(as based on FDA submission; april 2001)
http://www.fda.gov/ohrms/dockets/ac/01/slides/3746s_09_aventis/
Organism
MIC
90
S. pneumoniae
< 0.008 - 0.25
S. pyogenes
< 0.015 - 0.06
H. influenzae
2.0 - 4.0
M. catarrhalis
0.12
L. pneumophila
0.03 - 0.12
C. pneumoniae
0.03 - 2
M. pneumoniae
0.25
C
max
/MIC
90max
AUC
24h
/MIC
90max
7.6
33.2
31.6
138
0.475
2.075
15.8
69.1
Activity will be good for
MIC
£
0.25 mg/L, but may
become problematic for
higher MICs