ACETYLCHOLINEESTERASE - PHENSERINE
COMPLEX
Yu et al 2001, J.Med.Chem. 44:4062-407
•The carbamylated enzyme only slowly hydrolyzes
•
• Phenserine is further stabilized by both hydrophobic and p electron interaction due to p-p stacking of the phenyl group of phenylcarbamate between the flanking phenyl moieties of
Phe 295 and Phe 297 
FARM 2146 - 2003-2004