Zwick et al, Trends in Molecular Medicine (2002) 8: 17-23
IMMUNOTOXIN CONJUGATES AND LIGAND
BINDING CYTOTOXIC AGENTS TO INHIBIT THE
RECEPTOR TYROSINE KINASE SIGNALING
•
Fusion/conjugaison
between immunotoxins and
specific ligand
•
•
Binding to cell surface
receptors
•
•
Internalization into the
endosome and translocation
to the cytosol
•
•
Inhibition of protein
synthesis
2003-2004