Bergson et al, (2003) TIPS, 24: 486-492
RECEPTEURS DOPAMINERGIQUES
AND DOPAMINE RECEPTOR-INTERACTING
PROTEINS
(DRIPs).
Ca
2+
ACTS AS A
SENSOR
NCS-1 attenuates D2 recepteur
desensitization in a Ca
2+
sensitive manner
Interaction between NCS-1 and
G-protein-coupled receptor
kinase 2 (GRK2)
•
is Ca
2+
dependent
•
blocks GRK2-mediated
phosphorylation of the D2-
receptor
FARM 2146 - 2003-2004