2/11/2004
FARM 2147 Fluoroquinolones
29
0.01
0.10
1.00
10.00
10
-2
1
FQ concentration
Text Box: Fraction of survivors
Fraction of survivors
10
-4
10
-6
10
-8
10
-10
MIC (99)
MPC (10)
R = H
R = OCH3
N
C
O
F
N
O
-
O
CH
3
HN
H
5
C
2
R
MIC 99        0.25          0.8
MPC 10        0.9             9
MPC/MIC     3.6           12
Dong et al; AAC 43:1756-1758
Bactericidal activity of FQs against Mycobaterium bovis 
Is there a SAR for emergence of resistance ?
PD160793     PD161148