Ubiquitin act as a sorting signal in early
endosomes
àconjugation with ubiquitin = means to
terminate
signalling by rapid downregulation of receptors at
the plasma membrane
Plic proteins interfere with the degradation of
ubiquitin-
substrates
à ä T1/2
T1/2 of GABA
receptors ä by
binding of the receptor to Plic
ðModulation of the surface expression of GABA
receptors
ðRapid adaptation of neural excitability