IMMUNOTOXIN CONJUGATES AND LIGAND
BINDING CYTOTOXIC AGENTS TO INHIBIT THE
RECEPTOR TYROSINE KINASE SIGNALING
 Fusion/conjugaison
between immunotoxins and
specific ligand
 Binding to cell surface
receptors
Internalization into the
endosome and translocation
to the cytosol
Inhibition of protein
synthesis
Zwick et al, Trends in Molecular Medicine (2002) 8: 17-23