• rapid
reuptake by the plasma membrane dopamine transporter
= DAT
• DAT is a member of Na+/Cl- coupled neurotransmitter transporter
family
• DAT is blocked by - cocaine
• DAT is a molecular gateway for toxins,
metamphétamine
• DAT is expressed at high level in
• caudate
• putamen (the most sensitive region to damage in Parkinson’s disease)