2/11/2004
FARM 2147
Fluoroquinolones
10
Nalidixic acid *
* Belg.
pat. 612,258 to Sterling Drugs, 1962
-
•
typical chemical features of
fluoroquinolones (
a
,
b
,
c
)
BUT a naphthridone
(N at position 8:
)
•
limited usefulness as drug
•
narrow antibacterial spectrum
(
Enterobacteriaceae
only)
•
short half-life (1.5h)
•
high protein binding (90%)
a
b
c
N
N
C
O
C
2
H
5
O
-
O
H
3
C