2/11/2004
FARM 2147 Fluoroquinolones
The
"first generation" of fluoroquinolones
1960
1970
1980
• Nalidixic
acid
• Oxolinic acid
• Cinoxacin
• Pipemidic acid
• Norfloxacin
• Pefloxacin
• Ofloxacin
• Ciprofloxacin
• Fleroxacin
• Rufloxacin
improved
anti Gram (-)
activity
t1/2 activity
3-4
h ++
11
h +
6 h
++
3-4
h +++
