RECEPTEURS METABOTROPIQUES
AU GLUTAMATE
Agonist binding site is located in the
large N-terminal extracellular domain
which is connected to the seven-
transmembrane G-protein-coupled
receptor by a cysteine rich linker
Residues within intracellular loops 2
and 3 appear to be crucial for G-
protein coupling selectivity and
activation
C-terminal tail contains residues that
are involved in the protein kinase C-
induced desensitization of the
receptor and in the interaction with
intracellular proteins
ECB: Extracellular domain
LB: ligand binding lobes
AM: allosteric modulators
Pelligrini-Giampietro et al, TiPS (2003) 24 461-470
FARM 2146 - 2003-2004