RECEPTOR TYROSINE KINASE-
INTRACELLULAR BINDING SITE
Catalyse of recepteur
autophosphorylation of
cytoplasmic
tyrosine residues
àDocking sites for Src
homology (SH) and
phosphotyrosine-binding
(PTB) containing molecules
(PLC, Src, …)
Recrutment of additional
effectors molecules
containing    SH2, SH3,
PTB,PH (pleckstrin) domain
ðActivation of a cascade of
intracellular biochemical
signals
Zwick et al, Trends in Molecular Medicine (2002) 8: 17-23
2003-2004