 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
• |
Abundantly
expressed in numerous brain areas,
|
|
|
including the
locus coerulus, hypothalamus, amygdala,
|
|
|
hippocampus,
nucleus accumbens, and neocortes
|
|
|
• |
colocalizes with noradrenaline, GABA
|
|
|
• |
Actions mediated through heterogeneous
G-protein
|
|
|
coupled
receptors, among which Y1, Y2 and Y5 receptor
|
|
subtypes
mediate CNS effects
|
|
|
• |
Y1 and Y5 receptorr activation is
anxiolytic
|
|
|
• |
Y2 receptor activation is anxiogenic like
|
|