2/11/2004
FARM 2147 Fluoroquinolones
nalidixic
acid
3. introduce a
piperazine *
From nalidixic acid to the
1st fluoroquinolone (1 of 4)
N
N
N
C
O
C
2
H
5
O
-
O
N
HN
N
N
C
O
C
2
H
5
O
-
O
H
3
C
pipemidic
acid *
shows longer half-life...
*
pyrido-2-3-pyrimidine
* Ger. Pat. to Roger Bellon, 1974