•GH-releasing hormone (GHRH) stimulates GH release through
binding to the GHRH
receptor (blue)
and increasing cAMP levels
•
•GH secretagogues
(GHSs) stimulate GH release through the GHS receptor (red) to increase intracellular
calcium levels.The endogenous ligand for the GHS receptor was not
known until the discovery of ghelin