TARGETS FOR DRUG ACTION
Transporters
Omeprazole
Proton pump (gastric mucosa)
Cardiac glycosides
Na+/K+ pump
Loop diuretics
Na+/K+/Cl- co-transporter (loop of Henle)
Probenecid
Weak acid carrier (renal tubule)
Reserpine
Noradrenaline uptake (vesicular)
Amphetamine
Methyldopa
Tricyclic antidepressants
Cocaine
Noradrenaline uptake1
Hemicholinium
Choline carrier (nerve terminal)
False substrates
Inhibitors
Carriers
From Pharmacology, Ed Rang et al (2003), Churchill Livingstone, p 25
2003-2004