2/11/2004
FARM 2147 Fluoroquinolones
14
nalidixic acid
* Belgian patent 863,429, 1978 to Kyorin
N
N
C
O
C
2
H
5
O
-
O
H
3
C
N
C
O
F
O
-
O
HN
N
CH
3
norfloxacin *
1978
2
1
3
combine all 3
features *...
From nalidixic acid to the
1st fluoroquinolone (1 of 4)
broader Gram(-) activity
less protein binding (50%)
longer half-life (3-4h)
* 6-fluoro-7-pyrimidino-quinoleine