Pharmacodynamics of telithromycin
(as based on FDA submission; april 2001)
Organism                          MIC90
S. pneumoniae     < 0.008 - 0.25
S. pyogenes     < 0.015 - 0.06
H. influenzae            2.0 - 4.0
M. catarrhalis                0.12
L. pneumophila          0.03 - 0.12
C. pneumoniae          0.03 - 2
M. pneumoniae               0.25
Cmax/MIC90max  AUC24h/MIC90max
        7.6           33.2
      31.6         138
        0.475          2.075
      15.8          69.1
Activity will be good for
MIC£ 0.25 mg/L, but may
become problematic for
higher MICs
http://www.fda.gov/ohrms/dockets/ac/01/slides/3746s_09_aventis/
FARM2147
2/11/2004