RECEPTEURS NMDA
A protonated H+-sensor stabilizes the NR1-NR2B
heterodimer in low-conductance state
Polyamines (spermine, spermidine) shield
the H+-sensor from protons thus attenuating the
inhibition by proton
and potentialising the influx of Ca 2+
Ifenprodil enhances
the sensitivity
to protons
From Chizh et al. TiPS 22: 636-642 (2001)
Interactions
between endogenous modulators and ifenprodil-like
selective antagonists of NR2B-containing NMDA receptors
FARM 2146 - 2003-2004