The "first generation" of fluoroquinolones
1970
1980
1960
t
1/2
activity
3-4 h
++
•
Norfloxacin
•
Nalidixic acid
11 h
+
•
Pefloxacin
•
Oxolinic acid
6 h
++
•
Ofloxacin
•
Cinoxacin
improved
anti Gram (-)
activity
3-4 h
+++
•
Pipemidic acid
•
Ciprofloxacin
•
Fleroxacin
•
Rufloxacin
19