From nalidixic acid to the
1st fluoroquinolone
(1 of 4)
norfloxacin
*
combine all 3
features *...
nalidixic acid
2
F
N
HN
1
1978
3
broader Gram(-) activity
less protein binding (50%
)
longer half-life (3-4h)
* Belgian patent 863,429, 1978 to Kyorin
* 6-fluoro-7-pyrimidino-quinoleine
14