• 41 amino acid neuropeptide
•
• Initiates the hypothalamic-pituitary-adrenal axis
response to stress
• Four CRF-related peptides
•
• Two G-protein-coupled CRF receptor subtypes (CRF 1/2)
•
• CRF1 receptor antagonists might be capable of blocking pathological CRF-mediated stress responses without producing unwanted side effects caused by a general suppression of hypothalamic-pituitary-adrenal axis activity
CORTICOTROPIN-RELEASING FACTOR
FARM 2146 - 2003-2004