2/11/2004
FARM2147
23
Inhibition of Protein Synthesis (1)
•Inhibition of peptidyl transferase activity
5S rRNA
Domain V
Domain II
Pocket: peptidyl transferase site
5S rRNA
V
II
Erythromycin A
2058
752
30S
50S
O
O
O
-cladinose
erm
Modified from Bryskier
(FDA presentation of KETEK®)
mef