The "first generation" of fluoroquinolones
1970
1980
1960
t1/2    activity
3-4 h      ++
 Norfloxacin
 Nalidixic acid
11 h        +
 Pefloxacin
 Oxolinic acid
  6 h       ++
 Ofloxacin
 Cinoxacin
improved
anti Gram (-)
activity
3-4 h      +++
 Pipemidic acid
 Ciprofloxacin
 Fleroxacin
 Rufloxacin
19