CORTICOTROPIN-RELEASING FACTOR
 41 amino acid neuropeptide
 Initiates the hypothalamic-pituitary-adrenal axis
   response to stress
 Four CRF-related peptides
 Two G-protein-coupled CRF receptor subtypes (CRF 1/2)
 CRF1 receptor antagonists might be capable of blocking
pathological CRF-mediated stress responses without
producing unwanted side effects caused by a general
suppression of hypothalamic-pituitary-adrenal axis
activity
FARM 2146 - 2003-2004