From nalidixic acid to the
1st fluoroquinolone
(1 of 4)
nalidixic acid
pipemidic acid *
O
O
O
O
C
3. introduce a
piperazine *
-
C
N
-
N
N
N
C
N
N
HN
5
5
shows longer half-life...
* Ger. Pat. to Roger Bellon, 1974
* pyrido-2-3-pyrimidine
13