 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
• |
41 amino acid neuropeptide
|
|
|
• |
Initiates the
hypothalamic-pituitary-adrenal axis
|
|
|
response to stress
|
|
|
• |
Four CRF-related peptides
|
|
|
• |
Two G-protein-coupled CRF receptor
subtypes (CRF 1/2)
|
|
• |
CRF1 receptor antagonists might be
capable of blocking
|
|
|
pathological
CRF-mediated stress responses without
|
|
|
producing
unwanted side effects caused by a general
|
|
|
suppression of
hypothalamic-pituitary-adrenal axis
|
|
|
activity
|
|