PATHWAYS OF GROWTH HORMONE (GH)
RELEASE FROM THE PITUITARY
• GH-releasing hormone (GHRH) stimulates GH release through binding to the GHRH receptor (blue) and increasing cAMP levels
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• GH secretagogues (GHSs) stimulate GH release through the GHS receptor (red) to increase intracellular calcium levels.  The endogenous ligand for the GHS receptor was not known until the discovery of ghelin
Kojima et al,
Trends Endocrinology & Metabolism
(2001) 12: 118-122