•
The carbamylated
enzyme only slowly
hydrolyzes
•
Phenserine is
further stabilized by
both hydrophobic
and
p
electron
interaction due to
p
-
p
stacking of the
phenyl group of
phenylcarbamate
between the flanking
phenyl moieties of
Phe 295 and Phe 297
Yu et al 2001, J.Med.Chem. 44:4062-407