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Agonist
binding site is located in the
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large
N-terminal extracellular domain
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which is
connected to the seven-
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transmembrane
G-protein-coupled
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receptor by a
cysteine rich linker
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Residues
within intracellular loops 2
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and 3 appear
to be crucial for G-
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protein
coupling selectivity and
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activation
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C-terminal
tail contains residues that
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are involved
in the protein kinase C-
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induced
desensitization of the
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receptor and
in the interaction with
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intracellular
proteins
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