Ubiquitin act as a sorting signal in early endosomes
àconjugation with ubiquitin = means to terminate
signalling by rapid downregulation of receptors at
the plasma membrane
Plic proteins interfere with the degradation of ubiquitin-
substrates à ä T1/2
T1/2 of GABA receptors ä by binding of the receptor to Plic
ðModulation of the surface expression of GABA receptors
ðRapid adaptation of neural excitability
TRAFFICKING AND MEMBRANE TARGETING OF GABAA RECEPTORS
FARM 2146 - 2003-2004