2/11/2004
FARM 2147 Fluoroquinolones
19
The "first generation" of fluoroquinolones
1960
1970
1980
• Nalidixic acid
• Oxolinic acid
• Cinoxacin
• Pipemidic acid
• Norfloxacin
• Pefloxacin
• Ofloxacin
• Ciprofloxacin
• Fleroxacin
• Rufloxacin
improved
anti Gram (-)
activity
t1/2    activity
3-4 h      ++
11 h        +
  6 h       ++
3-4 h      +++