Discovery of its importance in stress-related disorders
Neuroanatomical studies
• The concentration of substance P is altered in neural circuits involving the amygdala, hypothalamus, hippocampus and periaqueductal gray
• Substance P has a unique anatomical relationship with monoamine neurotransmettors through which which clinically used antidepressant drugs mediate their therapeutic effects
Pharmacological blockade or genetic deletion
Pharmacological effect
Central injection of substance P elicits a range of behavorial and cardivascular stress responses in rats and guinea-pigs
SUBSTANCE  P
Holmes et al, TIPS, 24:580-588 (2003)
FARM 2146 - 2003-2004