|
|
|
The main problem due to interactions between
some macrolides and the cytochrome P 450 system, especially the CYP3A
subclass of enzymes |
|
Finally results in lowered metabolism of
CYP3A-dependent drugs |
|
______________________________________________________________________ |
|
drug azi clari diri ery josa mid roxi spira |
|
______________________________________________________________________________ |
|
théophyllin 0 0 0 ++ + ND 0/+ 0 |
|
ciclosporin ND ND ND +++ +++ +++ + 0 |
|
carbamazepin ND 0/+ ND +++ + + 0/+ 0/+ |
|
midazolam 0 ++ ND ++ ND ND + ND |
|
warfarin 0 ND ND + ND ND 0 ND |
|
terfenadin 0 ++ ND +++ 0/+ ND 0 ND |
|
cisapride ND ++ ND ++ ++ ND ND 0 |
|
______________________________________________________________________________ |
|
From Petitjean et
al. N=undocumented |
|
Mainly considered as a class-effect, resulting
from what is known for erythromycin, except for spira and azithromycin |
|
|