Other severe toxicities

1992:

The temafloxacin syndrome:

hemolytic uraemic anemia

• discoloured urine, fever

• jaundice, nausea, vomiting

• abdominal pain

• coagulopathy

• hepatic and renal dysfunction

• 0.056% incidence

• 2 deaths

withdrawn in June 1992

1999:

The trovafloxacin syndrome:

serious hepatic events

• laboratory abnormallities
  • ALT, bilirubin,  encephalopathies
  • necrotic inflammation

• 0.0056% incidence

• 5 transplants

• 6 deaths (multifactorial)

withdrawn / limited in June 1999

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