SAR of frequent side effects

N

X

8

COO-

O

R

5

F

R

7

R

1

Phototoxicity

Inhibition of P450

Inhibition of P450

N

Binding to

GABA receptor

Penetration

in CNS

R

HN

N

R

R

R

sparflo,

flero,

lomeflo

Ca++, Al+++, Fe++ complexation

cipro,

grepa ...

All FQs

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