Is there a SAR for emergence of resistance ?

0.01

0.10

1.00

10.00

10

-2

1

FQ concentration

Fraction of survivors

10

-4

10

-6

10

-8

10

-10

MIC (99)

MPC (10)

R = H

R = OCH3

MIC 99 0.25 0.8

MPC 10 0.9 9

MPC/MIC 3.6 12

Dong et al; AAC 43:1756-1758

Bactericidal activity of FQs against Mycobaterium bovis

PD160793 PD161148

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