Improving Gram (+) activity (S. pneumoniae)

N

X

8

COOH

O

R

5

F

R

7

R1

if X8 = C

Cl, F halogen

O-CH3 methoxy

N

N

H

2

N

F

F

CH3

pyrimidine

naphthyridone

bulky group

MIC

Gram (+)

Gram (+)

Gram (+)

MIC

Previous slide

Next slide

Back to first slide

View graphic version