From second to third generation of fluoroquinolones

1960

1970

1980

1990

2000

• Trovafloxacin b

• Moxifloxacin c

• Clinafloxacin a

• Gemifloxacin d

anti-Gram (-)

anti-Gram (+)

anti-anaerobe

a:Kyorin, 1987; b: Pfizer, 1993; c: Bayer, 1994; d: LG Chemical Ltd., S. Korea, 1994-98

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