From nalidixic acid to 1st generation

N

N

C

O

C

2

H

5

O

-

O

H

3

C

N

C

O

F

O

-

O

HN

N

-

H

3

C

O

CH

3

N

C

O

O

-

O

N

N

CH

3

CH

3

-

H

3

C

N

C

O

O

-

O

N

N

F

F

nalidixic acid

norfloxacin

ofloxacin*

* Eur. pat. Appl. 47,005 to Daiichi, 1982

pefloxacin

Tricyclic compound

(morpholine ring)

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