An what about ertapenem ?

The major ertapenem resistance seen in PAO-1 is not due to D2 loss,

OprM overexpression or ?la constitutivity - suggesting a new mechanism

Susceptibility Patterns of Resistant Mutants (PAO -1 and Derivatives)

MK- X + Ind + 32 2 2 4 0.5

0.5

64

1

2

16

+

Con

+

?la?

4

16

4

1

32

?

Ind

+

OprM (efflux)?

0.5

2

2-4

8-16

8

+

Ind

-

D2 (porin) ?

0.5

2-4

0.5-1

1-2

4-8

+

Ind

+

None (PAO-1)

LVF

CAZ

MER

IPM

ETP

OprM

?-la

D2

Resistance mechanism

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