Contribution of resistance mechanisms to carbapenem resistance in Pseudomonas

1 0.5

8 - 16 2 - 4

16 16

2. Clinical strains

AmpC MexAB ?OprD

# 1 low - -

# 2 low - +

# 3 low + +

Resistance mechanism

MIC

IMI MERO

Pai et al. AAC (2001) 45:480-484

Meropenem is affected by the expression of Mex AB (efflux)