Contribution of resistance mechanisms to carbapenem resistance in Pseudomonas

AmpC MexAB ?OprD

+ - -

- + -

- - +

Resistance mechanism

fold increase in MIC

IMI MERO

X 1 X 2

X 1 X 2 - 10

X 16 X 4

Kohler et al. AAC (1999) 43: 424-427

Nakae et al. AAC (1999) 43:1301-1303

1. Laboratory strains