Efflux and selection of resistance to FQ
Frequency of Levofloxacin-resistant mutants in
Pseudomonas aeruginosa with deletions of the efflux pump operons
Pump status LVX MIC Frequency of LVX- resistant mutants
WT 0.25 2 × 107 - 4 × 107
? mexAB-oprM 0.015 2 × 107 - 4 × 107
? mexCD-oprJ 0.25 2 × 107 - 4 × 107
? mexEF-oprN 0.25 2 × 107 - 4 × 107
? mexAB-oprM;? mexEF-oprN 0.015 2 × 107 - 107
? mexCD-oprJ; ? mexEF-oprN 0.25 2 × 106
? mexAB-oprM; ? mexCD-oprJ 0.015 1 × 109
? mexAB-oprM; ? mexCD-oprJ; 0.015 ə × 1011
Selection of mutants in FQ target
undetectable if ALL pumps are disrupted