From vancomycin to oritavancin

O

O

N

H

H

N

N

H

H

N

N

H

O

H

O

C

l

O

O

O

O

H

O

O

H

O

N

H

C

H

3

H

N

O

H

O

O

C

O

H

C

O

N

H

2

C

l

O

O

H

H

O

H

O

O

O

H

3

C

C

H

3

H

N

O

H

lipophilic side chain

• activity

including against resistant enterococci

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