Glycopeptides: what can we improve ?

spectrum

PD

vanco - teico

ideal glycopeptide

Gram (+) & MRSA

but VRE - GISA

static or slowly

bactericidal

PK

high doses to reach

appropriate

AUC/MIC & Cmax/MIC

safety

(red-man syndrome)

oto-& nephrotoxicity

t ½ short for vanco

PK/PD

parameter

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