Glycopeptide story: from natural to semi-synthetic derivatives

~ 1950 :

discovery of vancomycin in Mississipi mud

~ 1985 :

large clinical use in USA

Gram(+) infections and digestive tract decontamination

Problem:

• toxicity of vancomycin due to impurities  ? better purification procedures

~ 1980 :

discovery of teicoplanin, as a natural GP with improved PK
• largely used in Europe

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