PPT Slide
In this pharmacological model *, sparfloxacin IS the most active in spite of a unfavourable MIC (1.4 µg/ml) and modest cellular accumulation (12 x)
Fluoroquinolones have a large subcellular bioavailability are highly bactericidal
Listeria m. and fluoroquinolones
Why don’t you use fluoroquinolones today ?
- too low intrinsic activity ** ...