MPC: importance du groupe méthoxy en C8

0.01

0.10

1.00

10.00

10

-2

1

FQ concentration

Fraction of survivors

10

-4

10

-6

10

-8

10

-10

R = H

R = OCH3

MIC 99 0.25 0.8

MPC 10 0.9 9

MPC/MIC 3.6 12

Dong et al; AAC 43:1756-1758

Activité bactéricide des FQs vis-à-vis de Mycobacterium bovis

PD160793 PD161148

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