Why did ISAP started ?
Our thinking in the late 80’s:
- anti-infective drug usage has long been irrational or not scientifically based on a pharmacodynamic point of view
- search for low doses for fear of toxicity
- “errors” in drug dosages at registration
- misunderstanding of “optimal schedules”
- pharmacokinetics was mostly used to establish “drug presence” rather than to make correlation with efficacy